Results 241 to 250 of about 29,746,039 (283)

SDF-1 keeps HSC quiescent at home

Blood, 2011
In this issue of Blood , Tzeng et al report on the generation of adult, conditional SDF-1–deficient mice in which HSC quiescence and endosteal niche localization are impaired.[1][1] The chemokine stromal cell–derived factor 1 (SDF-1; CXCL12), and its major receptor CXCR4, regulate many ...
Tomer, Itkin, Tsvee, Lapidot
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Functional Characterization of SDF-1 Proximal Promoter

Journal of Molecular Biology, 2005
Stromal-cell derived factor 1 (SDF1) is a CXC chemokine that binds and signals through the CXCR4 receptor, playing an essential role in embryonic B lymphopoiesis, myelopoiesis and organogenesis. The CXCR4/SDF1 pathway is associated with several pathologies.
Carelia, García-Moruja, Juan M, Alonso-Lobo, Patricia, Rueda, Carmen, Torres, Nuria, González, Mercedes, Bermejo, Francisco, Luque, Fernando, Arenzana-Seisdedos, José, Alcamí, Antonio, Caruz   +9 more
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SDF-1 is an antifibrotic mediator in vivo

Mechanisms of lung injury and repair, 2020
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease and associated with high mortality. Excessive deposition of extracellular matrix by activated myofibroblasts in the alveolar interstitial space leads to scar formation that hinders gas exchange.
Amiq Gazdhar, Kleanthis Fytianos, Ronja Schliep, Sofia Mykoniati, Petra Khan, Katrin Hostettler, Lars Knudsen, Thomas Geiser   +7 more
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SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1/CXCR4 axis in bone defect

Journal of Bone and Mineral Metabolism, 2020
Recent studies have indicated the potential of stem cell therapy in combination with cytokines to restore the bone repair via migration and homing of stem cells to the defected area. The present study aimed to investigate the mobilization and recruitment of mesenchymal stem cells (MSCs) in response to SDF-1.Herein, the knockout rat model of the bone ...
Heli, Zhang, Xijing, Li, Junfeng, Li, Lili, Zhong, Xue, Chen, Si, Chen   +5 more
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SDF-1: the repulsive chemokine

Immunology Today, 2000
1 Mark C. Poznansky et al. (2000) Active movement of T cells away from a chemokine. Nat. Med. 6, 543–548Chemokines set up concentration (or chemotactic) gradients in tissue, which influence target cells to migrate towards their source – ‘up’ concentration gradients.
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Increase in Circulating SDF‐1 after Treatment with Sulfated Glycans

Annals of the New York Academy of Sciences, 2001
Abstract: SDF‐1 is a potent chemoattractant for mature white blood cells and hemopoietic stem/progenitor cells (HPCs). An important role for this chemo‐kine in mobilization has been postulated, but in vivo studies directly addressing its effects are lacking.
E A, Sweeney, T, Papayannopoulou
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SDF-1 Signaling in Myeloid Malignancies,

Blood, 2011
Abstract Abstract 3824 The factor SDF-1 (stromal derived factor-1) was identified as an important chemoattractant factor produced by bone marrow cells. SDF-1 acts on its receptor CXCR4 and plays primordial function in migration, retention and development of hematopoietic progenitors in bone marrow.
Rita de Cassia Carvalho Melo, Carolina Bigarella, Matheus Manolo Arouca, Mariana Ozello Baratti, Fabiola Traina, Sara T Olalla Saad   +5 more
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Chemosensitivity Is Differentially Regulated by SDF-1/CXCR4 and SDF-1/CXCR7 Axes in Acute Lymphoblastic Leukemia.

Blood, 2012
Abstract Abstract 2441 SDF-1 (CXCL12) is a chemokine vastly secreted from bone marrow-stromal cells (BM-SC), and plays a pivotal role for multiple biological events in a variety of cells. Hematopoietic stem cells express its receptor CXCR4 at high levels and the SDF-1/CXCR4 system is profoundly implicated in their homing ...
Norie Ando, Yoshiyuki Furuichi, Shin Kasai, Keiko Kagami, Kumiko Goi, Takeshi Inukai, Kanji Sugita   +6 more
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Plasma Levels of SDF-1 and Expression of SDF-1 Receptor on Multiply Myeloma Cells of Human Multiply Myeloma.

Blood, 2004
Abstract Multiple myeloma(MM) is a monoclonal expansion of malignant cells with a plasmablast-plasma cell morphology that is almost exclusively localized to the bone marrow, except at the final stages of disease, when they proliferate in the extramedullary area.
Caixia Li, De Pei Wu, Junjie Cao, Xiaojin Wu, Xiao Ma, Xueguang Zhang   +5 more
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[The expressions and the roles of SDF-1/CXCR-4 and SDF-1/CXCR-4 in human endometriosis].

Zhonghua yi xue za zhi, 2018
Objective: To investigate the expressions and significances of SDF-1 and its receptor CXCR-4 in endometriosis. Methods: 50 hysteromyoma patients treated at Beijing Tongren Hospital, Capital Medical University between 1(st) January 2016 and 31(st) December 2017 were divided into control group, that is, non-endometriosis group, while another 50 ...
Z, Ouyang, J P, Sun, X L, Tian, M X, Chen, J J, Zhai   +4 more
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