Results 41 to 50 of about 41,193 (292)

Imposter phenomenon and basic psychological needs predict self-evaluations of knowledge and ability relative to others

International Journal of Personality Psychology
Imposter Phenomenon (IP) is a set of psychological experiences characterized by self-doubt, attributing success to external causes, and a constant fear of being perceived as a phony (Clance & Imes, 1978), which may be suggestive of dissatisfaction with ...
Viktoria Biblekaj, Patricia Kahlbaugh
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Leprfa Rat: A New Obese Type 2 Diabetic Model

Journal of Diabetes Research, 2013
Spontaneously Diabetic Torii Leprfa (SDT fatty) rat, established by introducing the fa allele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes.
Yusuke Kemmochi, Kenji Fukui, Mimi Maki, Shuichi Kimura, Yukihito Ishii, Tomohiko Sasase, Katsuhiro Miyajima, Takeshi Ohta   +7 more
doaj   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Advanced Science, 2021
As a novel noninvasive therapeutic modality combining low‐intensity ultrasound and sonosensitizers, sonodynamic therapy (SDT) is promising for clinical translation due to its high tissue‐penetrating capability to treat deeper lesions intractable by ...
Zhuoran Gong, Zhifei Dai
doaj   +1 more source

MP-SDT induces intracellular ROS generation.

, 2019
(A) Representative fluorescence images of fluorescence of DCF in the control, ultrasound and MP-SDT groups. Scale bar = 50 μm. (B) Relative fluorescence intensity of DCF of indicated groups. (C) Representative fluorescence images of untreated macrophages
Zhiguo Zhang (147197), Mingyu Liu (248120), Zhengyu Cao (673219), Hong Jin (65601), Xuezhu Zhao (6817868), Xin Sun (127355), Tianyi Zhang (87298), Ye Tian (220278), Zhaoqian Shen (6817865), Bicheng Li (647182)   +9 more
core   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Sonodynamic therapy reduces iron retention of hemorrhagic plaque

Bioengineering & Translational Medicine, 2021
Intraplaque hemorrhage (IPH) plays a major role in the aggressive progression of vulnerable plaque, leading to acute cardiovascular events. We previously demonstrated that sonodynamic therapy (SDT) inhibits atherosclerotic plaque progression.
Bicheng Li, Jie Gong, Siqi Sheng, Minqiao Lu, Shuyuan Guo, Jianting Yao, Haiyu Zhang, Xuezhu Zhao, Zhengyu Cao, Xin Sun, Huan Wang, Yang Cao, Yongxing Jiang, Zhen Tian, Bin Liu, Hua Zhao, Zhiguo Zhang, Hong Jin, Ye Tian   +18 more
doaj   +1 more source

Outcome-framing manipulation with direct connection to SDT performance

, 2022
As the last two studies produced no SDT effects of RF, this study seeks to evaluate whether a manipulation of RF using outcomes that derive directly from performance in the SDT will prove more ...
Anand Krishna
core   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source