Results 81 to 90 of about 41,193 (292)

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Created Ex Nihilo: A Near‐Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging

Angewandte Chemie, EarlyView.
A series of Ir(III) complexes (Ir‐1‐Ir‐4) based on imidazole derivatives provide a new afterglow luminescence mechanism. The work expands the range of afterglow luminescence frameworks to overcome: (i) a lack of new afterglow scaffolds; (ii) the dependence on initial external light activation; and (iii) aggregation‐caused quenching.
Zihan Wu, Liping Zhang, Ziwei Wang, Yachao Wang, Gelin Xu, Feng Chi, Dongxia Zhu, Martin R. Bryce, Ben Zhong Tang, Lijie Ren   +9 more
wiley   +2 more sources

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

MP-SDT induces plasma membrane perforation.

, 2019
(A) Representative SEM and TEM images of the control, ultrasound and MP-SDT groups. Upper panel scale bar = 5 μm. Lower panel scale bar = 500 nm. (B) Quantitative assay of pore number per cell in the ultrasound and MP-SDT groups by SEM images.
Zhiguo Zhang (147197), Mingyu Liu (248120), Zhengyu Cao (673219), Hong Jin (65601), Xuezhu Zhao (6817868), Xin Sun (127355), Tianyi Zhang (87298), Ye Tian (220278), Zhaoqian Shen (6817865), Bicheng Li (647182)   +9 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Positional cloning of sdt.

, 2016
(a) The phenotype of parental plants. Scale bar: 20 cm. (b) Mature plant appearance of CSSLs. Scale bar: 20 cm. (c) In the fine-scale map, the QTL falls in the candidate region between markers 3517P2 and 3565P2 using 2,696 BC1F2 segregants, and the ...
Meng Zhao (54299), Xiangdong Fu (2213998), Shixia Huang (11609), Binmei Liu (580423), Qian Liu (135614), Shuansuo Wang (2214001), Ruixi Han (2213992), Kun Wu (286745), Yi Wang (32470), Yafeng Ye (2213995), Yuejin Wu (560004)   +10 more
core   +1 more source

Deposition Rate‐Controlled Functional Evolution of p‐Type Selenium‐Alloyed Tellurium–Tellurium Oxide Films for Thin‐Film Transistors

Advanced Science, EarlyView.
This study investigates the effects of thermal deposition rate on next‐generation p‐type amorphous oxide semiconductor SeTe–TeOx films. Deposition rate governs the chemical states, microstructure, and electrical characteristics of the films, resulting in tunable device properties.
Seongmo Kang, Jeong‐Min Seo, Hyungyu Choi, Yunseo Song, Tae Woong Yoon, Tae Woong Han, Hoseong Shin, Jiyun Lee, Boseok Kang   +8 more
wiley   +1 more source

Subquantum detection theory—SDT [PDF]

Physica E: Low-dimensional Systems and Nanostructures, 2010
Abstract We show that the cornerstone of QM—Born's rule—can be obtained from “subquantum detection theory” (SDT). This detection theory is based on purely classical field model for “quantum particles”. Electrons, photons, etc., neutrons are represented as classical waves fluctuating on a very fine time scale, constituting subquantum random fields.
openaire   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source