Results 161 to 170 of about 136,579 (306)

Sea Ice Modelling and Forecasting [PDF]

, 2018
Bouillon, Sylvain, Rampal, Pierre, Olason, Einar   +2 more
openaire   +1 more source

Anatomy of Arctic and Antarctic sea ice lows in an ocean–sea ice model

Abstract. Sea ice has exhibited a number of record lows in both hemispheres over the past two decades. While the causes of individual sea ice lows have already been investigated extensively, no systematic comparison across events and hemispheres has been conducted in a consistent framework yet.
Benjamin Richaud, François Massonnet, Thierry Fichefet, Dániel Topál, Antoine Barthélemy, David Docquier   +5 more
openaire   +2 more sources

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Top-Down and Bottom-Up Processes Jointly Explain Mesopredator Movement and Foraging Ecology. [PDF]

Ecol Lett
Florko KRN, Ross TR, Ferguson SH, Northrup JM, Obbard ME, Thiemann GW, Yurkowski DJ, Auger-Méthé M.   +7 more
europepmc   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Synchronous mid-Holocene marine and terrestrial deglaciation in the Ross Sea, Antarctica. [PDF]

Nat Commun
Parker RL, Riesselman CR, Truax OJ, Jones RS, Lee JI, Lee MK, Jacobsen G, Rosenheim BE, Subt C, Zawadzki A, Ginnane C, Naeher S, Dunbar G, McKay RM, Levy R, Turnbull J, Yoo KC.   +16 more
europepmc   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Separating tectonic and climate signals in Holocene sea-level records using marine terraces in central Chile. [PDF]

Sci Rep
Melnick D, Jara-Muñoz J, Garrett E, Plissart G, Freisleben R, Strecker MR.   +5 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Causes and consequences of Arctic amplification elucidated by coordinated multimodel experiments. [PDF]

Commun Earth Environ
Screen JA, Audette A, Blackport R, Deser C, England M, Feldl N, Gervais M, Hay S, Kushner PJ, Liang YC, Msadek R, Mudhar R, Sigmond M, Smith D, Sun L, Yu H.   +15 more
europepmc   +1 more source