Results 101 to 110 of about 11,361,094 (291)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sea-level change and storm surges in the context of climate change [PDF]

, 2000
This paper reviews the latest research in New Zealand surrounding the issues of sea-level rise and extreme sea levels in the context of global warming and variability in the Pacific-wide El Nino– Southern Oscillation (ENSO).
Bell, Robert G., de Lange, Willem P., Goring, D. G.   +2 more
core  

Estimating the cost of sea level rise

Marine Development
Sea level rise exacerbates flood risk for coastal communities globally. Multiple studies have shown that significant property values are already at risk this century, especially in high-emission scenarios. Thus, sea level rise poses major challenges that
Magnus Hieronymus, Jim Hedfors, Lisa Van Well, Gunnel Göransson, Sebastian Bokhari Irminger, Åke Magnusson   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Economy-Wide Impacts of Climate Change: A Joint Analysis for Sea Level Rise and Tourism [PDF]

While climate change impacts on human life have well defined and different origins, the interactions among the diverse impacts are not yet fully understood. Their final effects, however, especially those involving social-economic responses, are likely to
Richard S.J. Tol, Francesco Bosello, Roberto Roson, Andrea Bigano   +3 more
core  

Twentieth-Century Global-Mean Sea Level Rise: Is the Whole Greater than the Sum of the Parts? [PDF]

, 2012
Confidence in projections of global-mean sea level rise (GMSLR) depends on an ability to account for GMSLR during the twentieth century. There are contributions from ocean thermal expansion, mass loss from glaciers and ice sheets, groundwater extraction,
Wada, Y., Fettweis, Xavier, Tamisiea, M. E., Tamisiea, Mark, White, Neil, Church, J. A., Huybrechts, Philippe, Wada, Yoshihide, Box, J.E., Tamisiea, M.E., Marzeion, B., Wake, L. M., Gregory, Jonathan, Church, J.A., Konikow, L., Bierkens, M.F.P., Church, John, Oerlemans, Johannes, Cogley, J.G., Oerlemans, J., van den Broeke, M., Marzeion, Ben, Box, J., Leclercq, P., Gregory, J.M., Leclercq, P.W., Bierkens, Marc, van de Wal, R., Leclercq, P. W., van de Wal, R.S.W., van den Broeke, M R., Cogley, J., Wake, L.M., Broeke, M.R. van den, White, N. J., Box, Jason, Hanna, Edward, Cogley, Graham, Fettweis, X., Bierkens, M. F. P., Van den Broeke, M. R., Van de Wal, R. S. W., Konikow, Leonard, Wake, Leanne, Gregory, J., Konikow, L. F., White, N., Cogley, J. G., Leclercq, Paul, van de Wal, Roderik, Gregory, Jonathan M., Wake, L., Church, J., Huybrechts, P., Tamisiea, M., Bierkens, M., Konikow, L.F., Hanna, E., White, N.J., Tamisiea, E., Box, J. E., van den Broeke, Michiel   +61 more
core   +2 more sources

Atlantic meridional overturning circulation stable over the last 150 years

Quaestiones Geographicae, 2019
The Atlantic Meridional Overturning Circulation (AMOC) describes the northward flow of warm, salty water in the upper layers, and the southward flow of colder water in the deep Atlantic layers.
Parker Albert, Ollier Clifford
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source