Results 131 to 140 of about 2,443,175 (254)

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, Volume 15, Issue 7, Page 1124-1143, July 2025.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

Formation of sea ice ponds from ice-shelf runoff, adjacent to the McMurdo Ice Shelf, Antarctica

open access: yesAnnals of Glaciology, 2020
Ponds that form on sea ice can cause it to thin or break-up, which can promote calving from an adjacent ice shelf. Studies of sea ice ponds have predominantly focused on Arctic ponds formed by in situ melting/ponding.
Grant J. Macdonald   +2 more
doaj   +1 more source

Seasonal and Regional Manifestation of Arctic Sea Ice Loss

open access: yesJournal of Climate, 2018
The Arctic Ocean is currently on a fast track toward seasonally ice-free conditions. Although most attention has been on the accelerating summer sea ice decline, large changes are also occurring in winter.
I. Onarheim   +3 more
semanticscholar   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, Volume 15, Issue 7, Page 1041-1053, July 2025.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

open access: yesFEBS Open Bio, Volume 15, Issue 7, Page 1176-1188, July 2025.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee   +5 more
wiley   +1 more source

The Importance of Ice Vertical Resolution for Snowball Climate and Deglaciation [PDF]

open access: yes, 2010
Sea ice schemes with a few vertical levels are typically used to simulate the thermodynamic evolution of sea ice in global climate models. Here it is shown that these schemes overestimate the magnitude of the diurnal surface temperature cycle by a factor
Abbot, Dorian S.   +2 more
core   +2 more sources

A sea of ice

open access: yes, 2011
Peer ...
Dachs, Ramón   +3 more
openaire   +1 more source

Capacity of a set of CMIP6 models to simulate Arctic sea ice drift

open access: yesAnnals of Glaciology
Evaluating CMIP6 model performance helps to improve the prediction of future changes in Arctic sea ice. We analyze the seasonal cycles, distribution, and evolution of sea ice in different regions from 1979 to 2014.
Xinfang Zhang   +2 more
doaj   +1 more source

Arctic sea ice variation in the Northwest Passage in 1979–2017 and its response to surface thermodynamics factors

open access: yesAdvances in Climate Change Research, 2021
Sea ice conditions in the Canadian Arctic Archipelago (CAA) play a key role in the navigation of the Northwest Passage (NWP). Limited by observed sea ice thickness data, the research of temporal and spatial variation of sea ice in the NWP is insufficient.
Xin-Yi Shen   +7 more
doaj  

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