Results 121 to 130 of about 141,462 (300)

Extraction and analysis of the sea ice parameter dataset of the Bohai Sea from 2011 to 2021 based on GOCI

Frontiers in Marine Science
The Bohai Sea and its surrounding areas are rich in oil and natural gas and play an important role in industry, agriculture and the economy. However, the Bohai Sea suffers severely from sea ice in the winter.
Ran Yan, Xi Zhang, Wenlong Bi, Ning Wang, Yiding Zhao, Luchuan Bi, Haipeng Guan, Yunbo Liu, Fuxi Duan, Meijie Liu   +9 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Temporal variability and trends of sea ice in the Kara Sea and their relationship with atmospheric factors

, 2019
In this paper, temporal variability and trends of sea ice in the Kara Sea and their correlations with local atmospheric forcing have been quantified and analyzed based on NSDIC SIC dataset and ECMWF ERA-Interim dataset from 1979 to 2017.
Xie, Zexiao, Duan, Chenglin, Dong, Sheng, Wang, Zhifeng   +3 more
core   +1 more source

Sea ice friction and Arctic sea ice dynamics

, 2010
A series of double-shear experiments were undertaken in the Environmental Test Basin at the Hamburgische Shiffbau-Versuchsanstalt (HSVA) in Hamburg. The aim of these experiments was to improve understanding of transient behaviour in sea ice friction. To this end we have fitted our experimental results to a rate- and state- dependent model of friction ...
Lishman, Ben, Sammonds, Peter, Feltham, Danny, Wilchinsky, Alex   +3 more
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Polar Sea Ice Monitoring Using HY-2A Scatterometer Measurements

Remote Sensing, 2016
A sea ice detection algorithm based on Fisher’s linear discriminant analysis is developed to segment sea ice and open water for the Ku-band scatterometer onboard the China’s Hai Yang 2A Satellite (HY-2A/SCAT).
Mingming Li, Chaofang Zhao, Yong Zhao, Zhixiong Wang, Lijian Shi   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Evaluation of the ArcIOPS sea ice forecasts during 2021–2023

Frontiers in Earth Science
The operational sea ice forecasts from the Arctic Ice Ocean Prediction System (ArcIOPS) during 2021–2023 are validated against satellite-retrieved sea ice concentration and drift data, in situ and reanalyzed sea ice thickness data.
Xi Liang, Zhongxiang Tian, Fu Zhao, Ming Li, Na Liu, Chunhua Li   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source