Results 131 to 140 of about 141,462 (300)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Rain and ice flagging of Envisat altimeter and MWR data [PDF]
, 2004 Altimetry range, wave height, and wind speed measurements are often corrupted by two effects over the ocean: rain and sea-ice. Radiometer measurements, which provide the altimetric wet troposphere correction, are similarly corrupted by the presence of ...
Lillibridge, J. +2 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
The last glaciation of Shetland : local ice cap or invasive ice sheet?
, 2013 Issue ISBN: 978-82-92-39488-5 This work is supported by the Carnegie Trust for the Universities of ScotlandThe question of whether the Shetland Islands were covered by an ice cap or by an ice sheet during the last glacial cycle (40–10 ka) remains ...
Hall, A. M.
core
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
, 2019 Observations over recent decades suggest that sea ice plays a significant role in global biogeochemical cycles, providing an active biogeochemical interface at the ocean-atmosphere boundary.
Roukaerts, Arnout +8 more
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Arctic, Antarctic, and Alpine ResearchSea-ice loss and increasing unpredictability have disturbed and harmed Arctic peoples and ecosystems. In addition, studies demonstrate that sea ice plays a key role in climate variability and air–sea CO2 exchanges. Sea-ice data sets provide environmental
Natasha Leclerc, Jochen Halfar
doaj +1 more source