Results 101 to 110 of about 929,986 (341)

Southern Ocean warming: Increase in basal melting and grounded ice loss [PDF]

, 2013
We apply a global finite element sea ice/ice shelf/ocean model (FESOM) to the Antarctic marginal seas to analyze projections of ice shelf basal melting in a warmer climate.
Determann, Jürgen, Hellmer, Hartmut, Timmermann, Ralph   +2 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Extraction and analysis of the sea ice parameter dataset of the Bohai Sea from 2011 to 2021 based on GOCI

Frontiers in Marine Science
The Bohai Sea and its surrounding areas are rich in oil and natural gas and play an important role in industry, agriculture and the economy. However, the Bohai Sea suffers severely from sea ice in the winter.
Ran Yan, Xi Zhang, Wenlong Bi, Ning Wang, Yiding Zhao, Luchuan Bi, Haipeng Guan, Yunbo Liu, Fuxi Duan, Meijie Liu   +9 more
doaj   +1 more source

Predicting September sea ice: Ensemble skill of the SEARCH Sea Ice Outlook 2008–2013 [PDF]

, 2014
Since 2008, the Study of Environmental Arctic Change Sea Ice Outlook has solicited predictions of September sea-ice extent from the Arctic research community.
Bitz, Cecilia M., Blanchard-Wrigglesworth, Edward, Hamilton, Lawrence C., Stroeve, Julienne   +3 more
core   +1 more source

Dataset for "Roles of marine biota in the formation of atmospheric bioaerosols, cloud condensation nuclei, and ice-nucleating particles over the North Pacific Ocean, Bering Sea, and Arctic Ocean"

, 2023
Kaori Kawana, Fumikazu Taketani, Kazuhiko Matsumoto, Takuma Miyakawa, Yugo Kanaya   +4 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Flexural and compressive strength of the landfast sea ice in the Prydz Bay, East Antarctic

, 2021
Qingkai Wang, Zhaoquan Li, Lü Peng, Zhijun Li   +3 more
openalex   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Modeling Experiment on the Grounding of an Ice Shelf in the Central Arctic Ocean During MIS 6 [PDF]

, 2003
High-resolution chirp sonar subbottom profiles from the Lomonosov Ridge in the central Arctic Ocean, acquired from the Swedish icebreaker Oden in 1996, revealed large-scale erosion of the ridge crest down to depths of 1000 m below present sea level ...
Jakobsson, Martin, Paton, Mark, Siegert, M   +2 more
core   +2 more sources