Results 101 to 110 of about 2,198,658 (258)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Ice area export from Laptev Sea, Feb – May, 1992 - 2014 [PDF]

, 2017
Purpose of this document is the documentation of the area flux estimates of sea ice out of the Laptev Sea published in Itkin & Krumpen (2017), Winter sea ice export from the Laptev Sea preconditions the local summer sea ice cover and fast ice decay, The ...
Thomas Krumpen (6961619), Krumpen, Thomas   +1 more
core   +1 more source

Extraction and analysis of the sea ice parameter dataset of the Bohai Sea from 2011 to 2021 based on GOCI

Frontiers in Marine Science
The Bohai Sea and its surrounding areas are rich in oil and natural gas and play an important role in industry, agriculture and the economy. However, the Bohai Sea suffers severely from sea ice in the winter.
Ran Yan, Xi Zhang, Wenlong Bi, Ning Wang, Yiding Zhao, Luchuan Bi, Haipeng Guan, Yunbo Liu, Fuxi Duan, Meijie Liu   +9 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Sea Ice Latent Heat Becomes More Active in the Arctic Sea Ice Energy Budget

Geophysical Research Letters
Arctic sea ice has experienced rapid decrease in recent decades. The sea ice property changes have altered its thermodynamic processes, enhancing the heat exchange among atmosphere‐ocean‐ice surface.
Yuang Liu, Lujun Zhang, Guorui Shi, Xi Liang   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Sea-ice salinity, chlorophyll a concentration, and total particulate matter concentrations from sea-ice cores at site Barrow2010_c5

, 2013
Sea-ice salinity, chlorophyll a concentration, and total particulate matter concentrations from sea-ice cores at site ...
Granskog, Mats A, Nicolaus, Marcel, Hudson, Stephen R, Mats A Granskog (7013027), Stephen R Hudson (7976255), Marcel Nicolaus (6887372), Chris Petrich (7976312), Petrich, Chris   +7 more
core   +1 more source

Evaluation of the ArcIOPS sea ice forecasts during 2021–2023

Frontiers in Earth Science
The operational sea ice forecasts from the Arctic Ice Ocean Prediction System (ArcIOPS) during 2021–2023 are validated against satellite-retrieved sea ice concentration and drift data, in situ and reanalyzed sea ice thickness data.
Xi Liang, Zhongxiang Tian, Fu Zhao, Ming Li, Na Liu, Chunhua Li   +5 more
doaj   +1 more source