Results 101 to 110 of about 141,462 (300)

Antarctic sea ice trends and its response to the Southern annular mode

, 2009
Includes bibliographical references (leaves 37-42).Sea ice covers vast regions of the Southern Ocean and impacts on the climate as well as the plant and animal life of the region.
Collins, Charine
core  

Barents Sea ice cover reflects Atlantic inflow [PDF]

, 2011
The recent Arctic winter sea-ice retreat is most pronounced in the Barents Sea. Using available observations of the Atlantic inflow to the Barents Sea and results from a regional ice-ocean model we assess the role of inflowing heat anomalies on sea-ice ...
Skagseth, Øystein, Årthun, Marius, Eldevik, Tor, Smedsrud, Lars Henrik   +3 more
core  

Simulated global-mean sea level changes over the last half-millennium [PDF]

, 2006
Simulations of the last 500 yr carried out using the Third Hadley Centre Coupled Ocean-Atmosphere GCM (HadCM3) with anthropogenic and natural (solar and volcanic) forcings have been analyzed.
Tett, S. F. B., Gregory, J. M., Lowe, J. A.   +2 more
core   +1 more source

Impacts of Climate Change on Arctic Sea Ice

, 2023
Satellite sensors record a downward trend in Arctic sea ice extent for all months (Figure 2; Fox-Kemper et al., 2021). This trend is particularly pronounced in the summer months (June to October) in which ice extent of the most recent five years (2018 ...
Aksenov, Y., Tsamados, M., Oltmanns, M., Blockley, E.W., Hewitt, H.T., Campbell, K., Screen, J.A.   +6 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Capacity of a set of CMIP6 models to simulate Arctic sea ice drift

Annals of Glaciology
Evaluating CMIP6 model performance helps to improve the prediction of future changes in Arctic sea ice. We analyze the seasonal cycles, distribution, and evolution of sea ice in different regions from 1979 to 2014.
Xinfang Zhang, Jari Haapala, Petteri Uotila   +2 more
doaj   +1 more source

A suite of coupled ocean-sea ice simulations examining the effect of regime shift in sea-ice thickness distribution on ice–ocean interaction in the Arctic Ocean [PDF]

Geoscientific Model Development
A major shift in Arctic sea ice occurred in 2007, transitioning from thicker, deformed ice to thinner, more uniform ice with reduced surface roughness. This abrupt change likely altered the dynamic and thermodynamic interactions between sea ice and ocean,
H. Sumata, H. Sumata, M. A. Granskog, P. Duarte   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source