Results 91 to 100 of about 2,198,658 (258)

A suite of coupled ocean-sea ice simulations examining the effect of regime shift in sea-ice thickness distribution on ice–ocean interaction in the Arctic Ocean [PDF]

Geoscientific Model Development
A major shift in Arctic sea ice occurred in 2007, transitioning from thicker, deformed ice to thinner, more uniform ice with reduced surface roughness. This abrupt change likely altered the dynamic and thermodynamic interactions between sea ice and ocean,
H. Sumata, H. Sumata, M. A. Granskog, P. Duarte   +3 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Reconstructing ice dynamics in the central sector of the last British-Irish Ice Sheet [PDF]

, 2010
The central sector (NW England and Scottish borders) of the last British-Irish Ice Sheet exhibits a palimpsest glacial geological and geomorphological signature characteristic of multi-phase ice flow and ice-marginal fluctuations. Despite its influential
LIVINGSTONE, STEPHEN,JOHN, Livingstone, Stephen John   +1 more
core  

Seasonal Arctic Sea Ice Prediction Using a Newly Developed Fully Coupled Regional Model With the Assimilation of Satellite Sea Ice Observations

Journal of Advances in Modeling Earth Systems, 2020
To increase our capability to predict Arctic sea ice and climate, we have developed a coupled atmosphere‐sea ice‐ocean model configured for the pan‐Arctic with sufficient flexibility.
Chao‐Yuan Yang, Jiping Liu, Shiming Xu
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Data on Physical Properties of Sea Ice in the Northern Barents Sea and Adjacent Arctic Basin From the Nansen Legacy Project

Geoscience Data Journal
Recent decline of sea ice in the Barents Sea represents a clear manifestation of the ongoing Arctic warming. This study presents a compilation of data sets on sea ice physics acquired during 2018–2022 during Nansen Legacy—a Norwegian multidisciplinary ...
Dmitry V. Divine, Adam Steer, Mats A. Granskog, Sebastian Gerland, Øyvind Foss, Anca Cristea, Polona Itkin, Malin Johansson, Emily Down, Agneta Fransson   +9 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Introduction of Voyage Environmental Information System (VEIS) for the Northern Sea Rout

, 2016
We introduce the dynamic composite algorithm from AMSR2 Level 2 sea-ice concentration (SIC) data to produce the dynamic daily SIC distribution which is currently moving to pilot production in jpeg and netcdf formats.
김민우, 양찬수, 김선화, 홍단비, 임학수, 김경옥, 김철호   +6 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source