Results 91 to 100 of about 2,111,624 (286)

Seasonal Arctic Sea Ice Prediction Using a Newly Developed Fully Coupled Regional Model With the Assimilation of Satellite Sea Ice Observations

Journal of Advances in Modeling Earth Systems, 2020
To increase our capability to predict Arctic sea ice and climate, we have developed a coupled atmosphere‐sea ice‐ocean model configured for the pan‐Arctic with sufficient flexibility.
Chao‐Yuan Yang, Jiping Liu, Shiming Xu
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Data on Physical Properties of Sea Ice in the Northern Barents Sea and Adjacent Arctic Basin From the Nansen Legacy Project

Geoscience Data Journal
Recent decline of sea ice in the Barents Sea represents a clear manifestation of the ongoing Arctic warming. This study presents a compilation of data sets on sea ice physics acquired during 2018–2022 during Nansen Legacy—a Norwegian multidisciplinary ...
Dmitry V. Divine, Adam Steer, Mats A. Granskog, Sebastian Gerland, Øyvind Foss, Anca Cristea, Polona Itkin, Malin Johansson, Emily Down, Agneta Fransson   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Introduction of Voyage Environmental Information System (VEIS) for the Northern Sea Rout

, 2016
We introduce the dynamic composite algorithm from AMSR2 Level 2 sea-ice concentration (SIC) data to produce the dynamic daily SIC distribution which is currently moving to pilot production in jpeg and netcdf formats.
김민우, 양찬수, 김선화, 홍단비, 임학수, 김경옥, 김철호   +6 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evidence for the stability of the West Antarctic Ice Sheet divide for 1.4 million years [PDF]

, 2016
Past fluctuations of the West Antarctic Ice Sheet (WAIS) are of fundamental interest because of the possibility of WAIS collapse in the future and a consequent rise in global sea level.
Sugden, David, Stuart, Finlay, Freeman, Stewart, Freeman, Stewart P.H.T., Woodward, John, Marrero, Shasta, Steig, Eric J., Stuart, Finlay M., Westoby, M. J., Westoby, Matt, Sugden, David E., Marrero, Shasta M., Freeman, Stewart P. H. T., Dunning, Stuart, Winter, Kate, Hein, Andrew, Westoby, Matthew J., Hein, Andrew S., Dunning, Stuart A., Steig, Eric, Steig, Eric.J., Hein, Andrew; id_orcid   +21 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Extraction and analysis of the sea ice parameter dataset of the Bohai Sea from 2011 to 2021 based on GOCI

Frontiers in Marine Science
The Bohai Sea and its surrounding areas are rich in oil and natural gas and play an important role in industry, agriculture and the economy. However, the Bohai Sea suffers severely from sea ice in the winter.
Ran Yan, Xi Zhang, Wenlong Bi, Ning Wang, Yiding Zhao, Luchuan Bi, Haipeng Guan, Yunbo Liu, Fuxi Duan, Meijie Liu   +9 more
doaj   +1 more source