Results 91 to 100 of about 929,986 (341)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A direct helicopter EM sea ice thickness inversion, assessed with synthetic and field data [PDF]

, 2007
Accuracy and precision of helicopter electromagneticHEM sounding are the essential parameters for HEM seaicethickness profiling. For sea-ice thickness research, thequality of HEM ice thickness estimates must be better than10 cm to detect potential ...
Haas, Christian, Pfaffling, A., Reid, J. E.   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Seasonal Arctic Sea Ice Prediction Using a Newly Developed Fully Coupled Regional Model With the Assimilation of Satellite Sea Ice Observations

Journal of Advances in Modeling Earth Systems, 2020
To increase our capability to predict Arctic sea ice and climate, we have developed a coupled atmosphere‐sea ice‐ocean model configured for the pan‐Arctic with sufficient flexibility.
Chao‐Yuan Yang, Jiping Liu, Shiming Xu
doaj   +1 more source

NEEM seasonal dO18 data for "Climate information preserved in seasonal water isotope at NEEM: relationships with temperature, circulation and sea ice"

, 2021
Minjie Zheng, Jesper Sjolte, Florian Adolphi, Bo Vinther, Hans Christian Steen‐Larsen, Trevor Popp, Raimund Muscheler   +6 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Data on Physical Properties of Sea Ice in the Northern Barents Sea and Adjacent Arctic Basin From the Nansen Legacy Project

Geoscience Data Journal
Recent decline of sea ice in the Barents Sea represents a clear manifestation of the ongoing Arctic warming. This study presents a compilation of data sets on sea ice physics acquired during 2018–2022 during Nansen Legacy—a Norwegian multidisciplinary ...
Dmitry V. Divine, Adam Steer, Mats A. Granskog, Sebastian Gerland, Øyvind Foss, Anca Cristea, Polona Itkin, Malin Johansson, Emily Down, Agneta Fransson   +9 more
doaj   +1 more source

Recent Change—Sea Ice [PDF]

, 2015
Sea ice conditions in the Baltic Sea have been systematically monitored for more than 100 years. All sea ice-related parameters display large interannual variability, but a change towards milder ice winters has been observed over the past 100 years: in particular, the annual maximum ice extent has decreased and the length of the ice season has become ...
Jari J. Haapala, Iina Ronkainen, Natalija Schmelzer, Marzenna Sztobryn   +3 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source