Results 71 to 80 of about 2,198,658 (258)

The Finnish Ice Service, its sea-ice monitoring of the Baltic Sea and operational concept

Frontiers in Marine Science
The Finnish Ice Service is part of the Finnish Meteorological Institute (FMI). Based on the mandate in the Finnish legislation, it provides information on the ice conditions in the Baltic Sea.
Patrick B. Eriksson, Jouni Vainio, Niko Tollman, Anni Jokiniemi, Aleksi Arola, Marko Mäkynen, Juha Karvonen, Antti Kangas   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Insolation and gacial meltwater influence on sea‐ice and circulation variability in the Northeastern Labrador Sea during the last glacial period [PDF]

, 2019
The variable amounts of ice rafted debris (IRD) and foraminifers in North Atlantic sediments are related to the abrupt, millennial-scale alteration from Greenland stadials to interstadials during the last glacial period and indicate past ice sheet ...
Sarah M. P. Berben, Voelker, Antje, Dokken, Trond Martin, Griem, Lisa, Jansen, Eystein, Lisa Griem, Trond M. Dokken, Antje H. L. Voelker, Berben, Sarah M. P., Dokken, Trond M., Voelker, Antje H.L., Berben, Sarah Miche Patricia, Eystein Jansen   +12 more
core   +1 more source

Oceanographic conditions beneath Fimbul Ice Shelf, Antarctica [PDF]

, 2012
Antarctic ice shelves play a key role in the global climate system, acting as important sites for the cooling of shelf waters, thereby facilitating deep and bottom water formation.
Abrahamsen, Einar Povl
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Exploring beneath the PIG Ice Shelf with the Autosub3 AUV [PDF]

, 2009
On 31st January 2009, two numbers: “range and bearing” flashing up on a laptop screen, indicated that Autosub3 had returned from its last mission beneath the Pine Island Glacier (PIG) Ice Shelf in the Western Antarctic.
Furlong, Maaten E, White, Davie, J.R. Perrett, M. Pebody, P. Stevenson, Stevenson, Peter, Webb, Andy, McPhail, Stephen D, D. White, M. E. Furlong, S. D. McPhail, Perrett, James R, A. Webb   +12 more
core   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Rain and ice flagging of Envisat altimeter and MWR data [PDF]

, 2004
Altimetry range, wave height, and wind speed measurements are often corrupted by two effects over the ocean: rain and sea-ice. Radiometer measurements, which provide the altimetric wet troposphere correction, are similarly corrupted by the presence of ...
Lillibridge, J., Quartly, G., Scharroo, R.   +2 more
core   +1 more source