Results 81 to 90 of about 2,111,624 (286)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Biomarker Distributions in (Sub)‐Arctic Surface Sediments and Their Potential for Sea Ice Reconstructions

Geochemistry, Geophysics, Geosystems, 2020
To evaluate the present sea ice changes in a longer‐term perspective, the knowledge of sea ice variability on preindustrial and geological time scales is essential.
Henriette M. Kolling, Ruediger Stein, Kirsten Fahl, Henrik Sadatzki, Anne deVernal, Xiaotong Xiao   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A rapid transition from ice covered CO2–rich waters to a biologically mediated CO2 sink in the eastern Weddell Gyre [PDF]

, 2007
Circumpolar Deep Water (CDW), locally called Warm Deep Water (WDW), enters the Weddell Gyre in the southeast, roughly at 25° E to 30° E. In December 2002 and January 2003 we studied the effect of entrainment of WDW on the fugacity of carbon dioxide (fCO2)
Hoppema, Mario, Baar, H. J. W., Bakker, D. C. E., Schröder, M., Baar, H. J. W. de, Schroeder, M., Hoppema, M., Schröder, Michael, Geibert, W., de Baar, H. J. W.   +9 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Capacity of a set of CMIP6 models to simulate Arctic sea ice drift

Annals of Glaciology
Evaluating CMIP6 model performance helps to improve the prediction of future changes in Arctic sea ice. We analyze the seasonal cycles, distribution, and evolution of sea ice in different regions from 1979 to 2014.
Xinfang Zhang, Jari Haapala, Petteri Uotila   +2 more
doaj   +1 more source

A suite of coupled ocean-sea ice simulations examining the effect of regime shift in sea-ice thickness distribution on ice–ocean interaction in the Arctic Ocean [PDF]

Geoscientific Model Development
A major shift in Arctic sea ice occurred in 2007, transitioning from thicker, deformed ice to thinner, more uniform ice with reduced surface roughness. This abrupt change likely altered the dynamic and thermodynamic interactions between sea ice and ocean,
H. Sumata, H. Sumata, M. A. Granskog, P. Duarte   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Antarctic sea ice control on ocean circulation in present and glacial climates [PDF]

, 2013
All authors acknowledge support from the National Science Foundation. R.F. acknowledges support from the Breene M. Kerr Chair.In the modern climate, the ocean below 2 km is mainly filled by waters sinking into the abyss around Antarctica and in the North
Burke, Andrea, Ferrari, Raffaele, Adkins, Jess F., Jansen, Malte F., Thompson, Andrew F., Stewart, Andrew L., Jansen, Malte Friedrich, Burke, Andrea, Ph. D. Massachusetts Institute of Technology   +7 more
core   +1 more source