Geochemistry, Geophysics, Geosystems, 2020 To evaluate the present sea ice changes in a longer‐term perspective, the knowledge of sea ice variability on preindustrial and geological time scales is essential.
Henriette M. Kolling +5 more
doaj +1 more source
Calibrating an ice sheet model using high-dimensional binary spatial data
, 2016 Rapid retreat of ice in the Amundsen Sea sector of West Antarctica may cause drastic sea level rise, posing significant risks to populations in low-lying coastal regions.
Applegate, Patrick +3 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Grounding of an Ice Shelf in the Central Arctic Ocean: A Modeling Experiment [PDF]
, 2003 A numerical ice sheet model was used in a first test towards evaluating the hypothesis that, during a period of large-scale glaciation, an ice shelf emanating from the Barents/Kara Seas grounded across parts of the Lomonosov Ridge to a depth of around ...
Jakobsson, Martin +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
SEASONAL VARIABILITY OF CENTRAL ARCTIC OCEAN SEA-ICE COVER: NEW BIOMARKER (IP25 AND PIP25) DATA FROM SEDIMENT TRAPS DEPLOYED ON SOUTHERN LOMONOSOV RIDGE [PDF]
, 2012 During the Polarstern 1995 Expedition, a long-term mooring system with two cone-shaped multi-sampling traps was deployed at the dominantly ice-covered western slope of the southern Lomonosov Ridge (81°04.5'N, 138°54.0'E, 1712 m water depth). One trap was
Fahl, Kirsten, Stein, Rüdiger
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Capacity of a set of CMIP6 models to simulate Arctic sea ice drift
Annals of GlaciologyEvaluating CMIP6 model performance helps to improve the prediction of future changes in Arctic sea ice. We analyze the seasonal cycles, distribution, and evolution of sea ice in different regions from 1979 to 2014.
Xinfang Zhang +2 more
doaj +1 more source
A suite of coupled ocean-sea ice simulations examining the effect of regime shift in sea-ice thickness distribution on ice–ocean interaction in the Arctic Ocean [PDF]
Geoscientific Model DevelopmentA major shift in Arctic sea ice occurred in 2007, transitioning from thicker, deformed ice to thinner, more uniform ice with reduced surface roughness. This abrupt change likely altered the dynamic and thermodynamic interactions between sea ice and ocean,
H. Sumata +3 more
doaj +1 more source