Results 61 to 70 of about 2,198,658 (258)

The relationship between sea ice bacterial community structure and biogeochemistry: A synthesis of current knowledge and known unknowns

Elementa: Science of the Anthropocene, 2015
Sea ice plays an important role in high latitude biogeochemical cycles, ecosystems, and climate. A complete understanding of how sea ice biogeochemistry contributes to these processes must take into account the metabolic functions of the sea ice ...
Jeff S. Bowman
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sea-ice thickness, snow depth, freeboard, scattering layer thickness, and sea-ice type at sea ice station PS78/230-1

, 2012
Sea-ice thickness, snow depth, freeboard, scattering layer thickness, and sea-ice type at sea ice station PS78/267-
James A Maslanik (6979643), Maslanik, James A, Nicolaus, Marcel, Christian Katlein (6962774), Stefan Hendricks (6887366), Hendricks, Stefan, Katlein, Christian, Marcel Nicolaus (6887372)   +7 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Barents Sea ice cover reflects Atlantic inflow [PDF]

, 2011
The recent Arctic winter sea-ice retreat is most pronounced in the Barents Sea. Using available observations of the Atlantic inflow to the Barents Sea and results from a regional ice-ocean model we assess the role of inflowing heat anomalies on sea-ice ...
Skagseth, Øystein, Årthun, Marius, Eldevik, Tor, Smedsrud, Lars Henrik   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Using Sea-Level Data to Constrain the Contribution of the Greenland Ice Sheet to Contemporary and Recent Sea-Level Change [PDF]

, 2010
Due to the potentially wide-reaching impacts on climate and sea-level change of a declining Greenland Ice Sheet (GrIS), the mass balance of the past decade has caused concern that the ice sheet is reacting to increased temperatures of the industrial era ...
Wake, Leanne Mary, WAKE, LEANNE,MARY
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Evidence for the stability of the West Antarctic Ice Sheet divide for 1.4 million years [PDF]

, 2016
Past fluctuations of the West Antarctic Ice Sheet (WAIS) are of fundamental interest because of the possibility of WAIS collapse in the future and a consequent rise in global sea level.
Sugden, David, Stuart, Finlay, Freeman, Stewart, Freeman, Stewart P.H.T., Woodward, John, Marrero, Shasta, Steig, Eric J., Stuart, Finlay M., Westoby, M. J., Westoby, Matt, Sugden, David E., Marrero, Shasta M., Freeman, Stewart P. H. T., Dunning, Stuart, Winter, Kate, Hein, Andrew, Westoby, Matthew J., Hein, Andrew S., Dunning, Stuart A., Steig, Eric, Steig, Eric.J., Hein, Andrew; id_orcid   +21 more
core   +1 more source