Results 151 to 160 of about 2,485,692 (404)
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
Does Marine Surface Tension Have Global Biogeography? Addition for the OCEANFILMS Package
Atmosphere, 2018 We apply principles of Gibbs phase plane chemistry across the entire ocean-atmosphere interface to investigate aerosol generation and geophysical transfer issues.
Scott Elliott +19 more
doaj +1 more source
The future sea-level contribution of the Greenland ice sheet: a multi-model ensemble study of ISMIP6
The Cryosphere, 2020 . The Greenland ice sheet is one of the largest contributors to global mean sea-level rise today and is expected to continue to lose mass as the Arctic continues to warm.
H. Goelzer +41 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Rain and ice flagging of Envisat altimeter and MWR data [PDF]
, 2004 Altimetry range, wave height, and wind speed measurements are often corrupted by two effects over the ocean: rain and sea-ice. Radiometer measurements, which provide the altimetric wet troposphere correction, are similarly corrupted by the presence of ...
Lillibridge, J. +2 more
core
Formation of sea ice ponds from ice-shelf runoff, adjacent to the McMurdo Ice Shelf, Antarctica
Annals of Glaciology, 2020 Ponds that form on sea ice can cause it to thin or break-up, which can promote calving from an adjacent ice shelf. Studies of sea ice ponds have predominantly focused on Arctic ponds formed by in situ melting/ponding.
Grant J. Macdonald +2 more
doaj +1 more source
The Role of Atlantic Heat Transport in Future Arctic Winter Sea Ice Loss
Journal of Climate, 2019 During recent decades Arctic sea ice variability and retreat during winter have largely been a result of variable ocean heat transport (OHT). Here we use the Community Earth System Model (CESM) large ensemble simulation to disentangle internally and ...
M. Årthun, T. Eldevik, L. Smedsrud
semanticscholar +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Understanding Sea Ice Melting via Functional Data Analysis [PDF]
arXiv, 2016 In this article, we considered the problem of sea ice cover is melting. Considering the `satellite passive microwave remote sensing data' as functional data, we studied daily observation of sea ice cover of each year as a smooth continuous function of time.
arxiv