Results 31 to 40 of about 878,327 (287)

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Modelling of sea-ice phenomena [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2018
The focus of the present theme issue is on significant recent advances in the understanding and modelling of floating sea ice. This also follows an extended and concerted research programme held in late 2017 at the Isaac Newton Institute in which the mathematics of sea-ice phenomena was addressed.
Frank Smith, Alexander Korobkin, Emilian Parau, Daniel Feltham, Vernon Squire   +4 more
openaire   +4 more sources

The reversibility of sea ice loss in a state-of-the-art climate model [PDF]

, 2011
Rapid Arctic sea ice retreat has fueled speculation about the possibility of threshold (or ‘tipping point’) behavior and irreversible loss of the sea ice cover. We test sea ice reversibility within a state-of-the-art atmosphere–ocean global climate model
Armour, K. C., Bitz, C. M., Blanchard-Wrigglesworth, E., Eisenman, I., McCusker, K. E.   +4 more
core  

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Modern spatial sea-ice variability in the central Arctic Ocean and adjacent marginal seas: Reconstruction from biomarker data [PDF]

, 2012
Sea ice is a fundamental component of Earth’s climate system, contributing to heat reduction (albedo) and deep-water formation. In order to understand processes controlling the recent dramatic reduction in Arctic sea-ice cover, it is essential to ...
Fahl, Kirsten, Meheust, Marie, Müller, Juliane, Stein, Rüdiger, Xiao, Xiaotong   +4 more
core  

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Light Transmission Through Arctic Sea Ice - Large-Scale Studies on Seasonality and Spatial Variability [PDF]

, 2013
Arctic sea ice has declined and become thinner and more seasonal during the last decade. One consequence of this is that the surface energy budget of the Arctic Ocean is changing.
Arndt, Stefanie, Katlein, Christian, Nicolaus, Marcel   +2 more
core  

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Influence of transport and ocean ice extent on biogenic aerosol sulfur in the Arctic atmosphere [PDF]

, 2012
The recent decline in sea ice cover in the Arctic Ocean could affect the regional radiative forcing via changes in sea ice-atmosphere exchange of dimethyl sulfide (DMS) and biogenic aerosols formed from its atmospheric oxidation, such as methanesulfonic ...
Barrie, LA, Bates, TS, Chan, E, Gong, SL, Ishizawa, M, Leaitch, WR, Levasseur, M, Li, SM, Maenhaut, Willy, Norman, A, Quinn, PK, Sharma, S, Tarasick, DW, Toom-Sauntry, D   +13 more
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source