Results 41 to 50 of about 12,913 (258)

Assessment of the High Resolution SAR Mode of the RADARSAT Constellation Mission for First Year Ice and Multiyear Ice Characterization

open access: yesRemote Sensing, 2018
Simulated compact polarimetry from the RADARSAT Constellation Mission (RCM) is evaluated for sea ice classification. Compared to previous studies that evaluated the potential of RCM for sea ice classification, this study focuses on the High Resolution ...
Mohammed Dabboor   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Sea ice classification using multi-frequency polarimetric SAR data [PDF]

open access: yesIEEE International Geoscience and Remote Sensing Symposium, 2003
This paper discusses the capability of the complex Wishart classifier for sea ice and classification using multifrequency, fully polarimetric SAR data. C-, L-, and P-band data acquired by the JPL AIRSAR in the Beaufort Sea was used. Classification using the unsupervised Wishart classifier is a two-stage process. An initial classification is required to
Scheuchl, B., Hajnsek, I., Cumming, I.G.
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Sea ice type classification in the Chukchi sea using deep learning

open access: yes, 2021
This poster is prepared for the annual EarthCube meeting, 2021.
Vahedi, Behzad   +6 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Assessment of ICESat‐2 Sea Ice Surface Classification with Sentinel‐2 Imagery: Implications for Freeboard and New Estimates of Lead and Floe Geometry

open access: yesEarth and Space Science, 2021
NASA's Ice, Cloud, and Land Elevation Satellite‐2 (ICESat‐2) mission launched in September 2018 and is now providing high‐resolution surface elevation profiling across the entire globe, including the sea ice cover of the Arctic and Southern Oceans.
A. A. Petty   +7 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

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