Results 131 to 140 of about 294,753 (307)

Finite-Element Sea Ice Model (FESIM), version 2 [PDF]

, 2015
. The Finite-Element Sea Ice Model (FESIM), used as a component of the Finite-Element Sea ice Ocean Model, is presented. Version 2 includes the elastic-viscous-plastic (EVP) and viscous-plastic (VP) solvers and employs a flux corrected transport ...
Danilov, Sergey, Iakovlev, Nikolay, Jung, Thomas, Kimmritz, Madlen, Schröter, Jens, Sidorenko, Dmitry, Timmermann, Ralph, Wang, Qiang   +7 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Antarctic Sea Ice variations 1973 - 1975 [PDF]

Variations in the extent and concentration of sea ice cover on the Southern Ocean are described for the three-year period 1973-75 using information derived from the Nimbus-5 passive microwave ...
Campbell, W. J., Carsey, F., Gloersen, P., Parkinson, C., Ramseier, R. O., Zwally, H. J.   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessment of Arctic sea ice simulations in cGENIE model and projections under RCP scenarios

Scientific Reports
Simulating and predicting Arctic sea ice accurately remains an academic focus due to the complex and unclear mechanisms of Arctic sea ice variability and model biases.
Di Chen, Min Fu, Xin Liu, Qizhen Sun
doaj   +1 more source

Satellite-derived ice data sets no. 2: Arctic monthly average microwave brightness temperatures and sea ice concentrations, 1973-1976 [PDF]

A summary data set for four years (mid 70's) of Arctic sea ice conditions is available on magnetic tape. The data include monthly and yearly averaged Nimbus 5 electrically scanning microwave radiometer (ESMR) brightness temperatures, an ice concentration
Comiso, J. C., Parkinson, C. L., Zwally, H. J.   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sea Ice Concentration Manifestation in Radar Signal at Low Incidence Angles Depending on Wind Speed

Remote Sensing
In previous studies, the possibilities of Ku-band radar measurements at low incidence angles were investigated for the task of sea ice detection. In this paper, the sensitivity of normalized radar cross-section to sea ice concentration is investigated at
Maria Panfilova, Vladimir Karaev
doaj   +1 more source

ERA-40 SST and Sea Ice Concentration Data [PDF]

, 2001
The lower boundary condition of sea surface temperature (SST) and sea-ice concentration (sic) is a critical forcing of the lower frequencies in multi-decadal global atmospheric reanalyses such as ERA-40. Partly in response to the ERA-40 project, new SST/sic data sets have been developed that are considerably improved over those available to the first ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source