Results 141 to 150 of about 288,973 (326)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Assessment of Arctic sea ice simulations in cGENIE model and projections under RCP scenarios

Scientific Reports
Simulating and predicting Arctic sea ice accurately remains an academic focus due to the complex and unclear mechanisms of Arctic sea ice variability and model biases.
Di Chen, Min Fu, Xin Liu, Qizhen Sun
doaj   +1 more source

The AutoICE Challenge [PDF]

The Cryosphere
Mapping sea ice in the Arctic is essential for maritime navigation, and growing vessel traffic highlights the necessity of the timeliness and accuracy of sea ice charts.
A. Stokholm, A. Stokholm, J. Buus-Hinkler, T. Wulf, A. Korosov, R. Saldo, L. T. Pedersen, D. Arthurs, I. Dragan, I. Modica, J. Pedro, A. Debien, X. Chen, M. Patel, F. J. P. Cantu, J. N. Turnes, J. Park, L. Xu, K. A. Scott, D. A. Clausi, Y. Fang, M. Jiang, S. Taleghanidoozdoozan, N. C. Brubacher, A. Soleymani, Z. Gousseau, M. Smaczny, P. Kowalski, J. Komorowski, D. Rijlaarsdam, J. N. van Rijn, J. Jakobsen, M. S. J. Rogers, N. Hughes, T. Zagon, R. Solberg, N. Longépé, M. B. Kreiner   +37 more
doaj   +1 more source

Ultraphytoplankton abundances and chlorophyll a concentrations in ice-covered waters of northern seas [PDF]

, 1999
Brigitte Robineau
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Sea Ice Concentration Manifestation in Radar Signal at Low Incidence Angles Depending on Wind Speed

Remote Sensing
In previous studies, the possibilities of Ku-band radar measurements at low incidence angles were investigated for the task of sea ice detection. In this paper, the sensitivity of normalized radar cross-section to sea ice concentration is investigated at
Maria Panfilova, Vladimir Karaev
doaj   +1 more source

Changes in photosynthetic carbon allocation in algal assemblages of Arctic sea ice with decreasing nutrient concentrations and irradiance [PDF]

, 2000
Thomas Möck, Rolf Gradinger
openalex   +1 more source

Sea surface temperature and sea ice concentration consistency in the Arctic

, 2018
Poster presented at the 19th GHRSST science meeting (XIX), Darmstadt, Germany, June 4 - 8, 2018.
openaire   +1 more source

On the Auto regressive Nature of Arctic Sea Ice Concentrations

Canadian Journal of Remote Sensing, 2001
Plusieurs experiences de modele general de circulation predisent un rechauffement croissant dans les regions polaires comme une des reponses les plus fortes a l'augmentation des concentrations des gaz a effet de serre. Dans cette optique, on s'interroge quant a la possibilite qu'un patron spatialement coherent observe dans les tendances des ...
J.M. Piwowar, E.F. LeDrew
openaire   +2 more sources

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source