Results 121 to 130 of about 2,824,835 (249)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

open access: yesAdvanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal   +21 more
wiley   +1 more source

Advancing Arctic Sea Ice Remote Sensing with AI and Deep Learning: Opportunities and Challenges

open access: yesRemote Sensing
Revolutionary advances in artificial intelligence (AI) in the past decade have brought transformative innovation across science and engineering disciplines.
Wenwen Li, Chia-Yu Hsu, Marco Tedesco
doaj   +1 more source

Angular and frequency correlation for sea-ice thickness retrieval

open access: yesIEEE International IEEE International IEEE International Geoscience and Remote Sensing Symposium, 2004. IGARSS '04. Proceedings. 2004, 2004
A combined spatial and frequency domain interferometer or angular and frequency correlation (ACF/FCF) between two radar beams in the VHF-band is applied for the direct measurement of sea-ice thickness. This measurement is critical because the thickness of sea ice within the polar region indicates the state of ocean circulation and the associated air ...
Ziad A. Hussein   +4 more
openaire   +1 more source

An assessment of key model parametric uncertainties in projections of Greenland Ice Sheet behavior [PDF]

open access: yes, 2012
Lack of knowledge about the values of ice sheet model input parameters introduces substantial uncertainty into projections of Greenland Ice Sheet contributions to future sea level rise.
Stone, Emma J.   +17 more
core   +2 more sources

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

open access: yesAdvanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou   +6 more
wiley   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj   +23 more
wiley   +1 more source

The last glaciation of Shetland : local ice cap or invasive ice sheet? [PDF]

open access: yes, 2014
Issue ISBN: 978-82-92-39488-5 This work is supported by the Carnegie Trust for the Universities of ScotlandThe question of whether the Shetland Islands were covered by an ice cap or by an ice sheet during the last glacial cycle (40–10 ka) remains ...
Hall, A. M.
core   +2 more sources

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

open access: yesAdvanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi   +10 more
wiley   +1 more source

Effects of the complexity of the ocean model on the sea ice data assimilation in a coupled sea ice-ocean model

open access: yesGeoscience Letters
The ocean plays a crucial role in the formation and melting of sea ice, which also affects the performance of sea ice data assimilation. To evaluate how ocean model complexity affects the assimilation performance, the sea ice model is separately coupled ...
Young-Chan Noh   +2 more
doaj   +1 more source

A Novel Drug‐Loaded Porous Parylene Electrode for Targeted Anti‐Inflammatory Therapy and Hearing Preservation in Cochlear Implantation

open access: yesAdvanced Healthcare Materials, EarlyView.
A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang   +11 more
wiley   +1 more source

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