Results 201 to 210 of about 10,989 (258)

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Sequence of abrupt transitions in Antarctic drainage basins before and during the Mid-Pleistocene Transition. [PDF]

Nat Commun
Wirths C, Hermant A, Stepanek C, Stocker TF, Sutter JCR.   +4 more
europepmc   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

Southern Ocean seabird population shifts over the Holocene revealed by peat sequestration of mercury from guano. [PDF]

Proc Natl Acad Sci U S A
Li C, Roberts SJ, Grosjean M, Mestrot A, Wille M, Phillips RA, Enrico M, Bishop K, Skyllberg U, Mauquoy D, von Scheffer C, Theurer T, Muirhead D, Whittle A, Gallego-Sala A, Sonke JE, De Vleeschouwer F, Van der Putten N, Braconnot P, Marti O, Osterwalder S, Buchmann N, Frölicher T, Anthamatten E, Chiaia-Hernández AC, Zahajská P, Jeandel C, Saunders KM, Kwon SY, Wang D, Bindler R, Sime L, Hodgson DA.   +32 more
europepmc   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Stress pinch points from glacial loading modulate magma ascent and storage in continental arcs. [PDF]

Nat Commun
Townsend M, Moreno-Yaeger P, Harp A, Huber C, Singer BS.   +4 more
europepmc   +1 more source

Breaking the Toughness‐Stretchability Trade‐Off in Hydrogels with Dynamic Hydrogen Bonding

Advanced Science, EarlyView.
A novel nanocomposite hydrogel architecture overcomes the inherent conflict between toughness and stretchability by integrating uniformly dispersed aminopropyl‐hybrid‐phyllosilicate nanosheets within a polyacrylamide matrix. This design leverages a dynamic hydrogen‐bonding network to facilitate efficient energy dissipation and self‐recovery.
Yining Gao, Yong Tao, Roland J.‐M. Pellenq, Fazhou Wang   +3 more
wiley   +1 more source

Repeated major inland retreat of Thwaites and Pine Island glaciers (West Antarctica) during the Pliocene. [PDF]

Proc Natl Acad Sci U S A
Horikawa K, Iwai M, Hillenbrand CD, Siddoway CS, Halberstadt AR, Cowan EA, Penkrot ML, Gohl K, Wellner JS, Asahara Y, Shin KC, Noda M, Fujimoto M, Expedition 379 Science Party.   +13 more
europepmc   +1 more source

Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice-Earth interactions in Greenland. [PDF]

Proc Natl Acad Sci U S A
Ajourlou P, Milne GA, Love R, Afonso JC, Afonso JC, Salajegheh F, Latychev K, Kjeldsen KK, Lepipas A, Martos YM, Woodroffe SA.   +10 more
europepmc   +1 more source

Configuration of circum-Antarctic circulation at the last green- to icehouse climate transition. [PDF]

Proc Natl Acad Sci U S A
Knahl HS, Klages JP, Ackermann L, Hochmuth K, Niu L, Golledge NR, Lohmann G.   +6 more
europepmc   +1 more source