Results 41 to 50 of about 137,897 (280)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Validation of SMOS sea ice thickness retrieval in the northern Baltic Sea [PDF]

, 2015
The Soil Moisture and Ocean Salinity (SMOS) mission observes brightness temperatures at a low microwave frequency of 1.4 GHz (L-band) with a daily coverage of the polar regions.
Drusch, Matthias, Haapala, Jari, Haas, Christian, Hendricks, Stefan, Kaleschke, Lars, Krumpen, Thomas, Lensu, Mikko, Maaß, Nina, Mäkynen, Marko, Tian–Kunze, Xiangshan   +9 more
core   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Will Arctic sea ice thickness initialization improve seasonal forecast skill? [PDF]

, 2014
Arctic sea ice thickness is thought to be an important predictor of Arctic sea ice extent. However, coupled seasonal forecast systems do not generally use sea ice thickness observations in their initialization and are therefore missing a potentially ...
Bitz, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Blanchard-Wrigglesworth, Chevallier, Chevallier, Collins, Day, Doblas-Reyes, Dunstone, E. Hawkins, Eicken, Guemas, Guemas, Holland, J. J. Day, Johns, Jung, Kaleschke, Koenigk, Koenigk, Latif, Laxon, Lindsay, Massonnet, Mathiot, McLaren, Persson, Pohlmann, S. Tietsche, Schröder, Serreze, Shaffrey, Sigmond, Stephenson, Stroeve, Tietsche, Tietsche, Wang, Yang   +39 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Sea ice thickness distribution in the Arctic Ocean

Cold Regions Science and Technology, 1987
Abstract Data from the unclassified literature were reviewed to determine the regional and seasonal distributions of sea ice thickness, pressure ridging statistics, frequency of occurrence of polynyas, and keel/sail height ratios. Seasonal and regional maps and histograms of these properties were constructed.
Bourke, Robert H., Garrett, Robert P.
openaire   +2 more sources

Arctic Sea Ice Thickness Estimation from CryoSat-2 Satellite Data Using Machine Learning-Based Lead Detection [PDF]

, 2016
Satellite altimeters have been used to monitor Arctic sea ice thickness since the early 2000s. In order to estimate sea ice thickness from satellite altimeter data, leads (i.e., cracks between ice floes) should first be identified for the calculation of ...
Hyun-cheol Kim, Jensen, Jensen, Jinwoo Kim, Jungho Im, Li, Lindi Quackenbush, Long, Miae Kim, Minso Shin, Salvatore, Sanggyun Lee   +11 more
core   +2 more sources