Results 71 to 80 of about 133,709 (318)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Empirical sea ice thickness retrieval during the freeze-up period from SMOS high incident angle observations [PDF]
The Cryosphere, 2014 Sea ice thickness information is important for sea ice modelling and ship operations. Here a method to detect the thickness of sea ice up to 50 cm during the freeze-up season based on high incidence angle observations of the Soil Moisture and ...
M. Huntemann +5 more
doaj +1 more source
The Grounding of an Ice Shelf in the Central Arctic Ocean: A Modeling Experiment [PDF]
, 2003 A numerical ice sheet model was used in a first test towards evaluating the hypothesis that, during a period of large-scale glaciation, an ice shelf emanating from the Barents/Kara Seas grounded across parts of the Lomonosov Ridge to a depth of around ...
Jakobsson, Martin +2 more
core +1 more source
Potential sea ice predictability and the role of stochastic sea ice strength perturbations [PDF]
, 2014 Ensemble experiments with a climate model are carried out in order to explore how incorporating a stochastic ice strength parameterization to account for model uncertainty affects estimates of potential sea ice predictability on time scales from days to ...
Goessling, Helge F. +2 more
core +2 more sources
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Sea-ice thickness from field measurements in the northwestern Barents Sea [PDF]
Journal of Geophysical Research: Oceans, 2017 The Barents Sea is one of the fastest changing regions of the Arctic, and has experienced the strongest decline in winter-time sea-ice area in the Arctic, at -23 +/- 4% per decade. Sea-ice thickness in the Barents Sea is not well studied. We present two previously unpublished helicopter-borne electromagnetic (HEM) ice thickness measurements from the ...
Caixin Wang +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Estimation of Arctic Sea Ice Thickness Using HY-2B Altimeter Data
Remote SensingSea ice thickness is an important component of the Arctic environment, bearing crucial significance in investigations pertaining to global climate and environmental changes.
Chunyu Pang +4 more
doaj +1 more source
Improving the WRF model's (version 3.6.1) simulation over sea ice surface through coupling with a complex thermodynamic sea ice model (HIGHTSI) [PDF]
Geoscientific Model Development, 2016 Sea ice plays an important role in the air–ice–ocean interaction, but it is often represented simply in many regional atmospheric models. The Noah sea ice scheme, which is the only option in the current Weather Research and Forecasting (WRF) model ...
Y. Yao, J. Huang, Y. Luo, Z. Zhao
doaj +1 more source
FEBS Open Bio, EarlyView.In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li +5 more
wiley +1 more source