Results 191 to 200 of about 465,794 (310)

Impacts of future sea level change on Greenland from community knowledge, coastal mapping, and glacial isostatic adjustment models. [PDF]

Proc Natl Acad Sci U S A
Tinto KJ, Austermann J, Bell RE, Blockley D, Brayton CE, Krawczyk D, Lewright L, Lloyd AJ, Nitsche FO, Paxman GJG, Porter DF, Sørensen A, Turrin M, Zinglersen K.   +13 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Modelling lung and muscle oxygen diffusion capacities from sea-level to Mount Everest. [PDF]

Sci Rep
Bourdillon N, Manferdelli G, Raberin A, Millet GP.   +3 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hydrostatic sea-level rise inundation impacts on ahu and harbors of Rapa Nui (Easter Island). [PDF]

Sci Rep
Paoa N, Fletcher CH, Barbee M, Anderson TR, Habel S, Wilkins Riroroko G, Pakarati Trengove S.   +6 more
europepmc   +1 more source

Why sea level is not level [PDF]

Past Global Changes Horizons, 2021
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The influence of non-oceanic forces on the mean sea level of the Brazilian coast: a bivariate and multivariate approach. [PDF]

Sci Rep
Junior NSR, Guedes EF, de Castro APN, da Silva Filho AM.   +3 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Separating tectonic and climate signals in Holocene sea-level records using marine terraces in central Chile. [PDF]

Sci Rep
Melnick D, Jara-Muñoz J, Garrett E, Plissart G, Freisleben R, Strecker MR.   +5 more
europepmc   +1 more source