Results 131 to 140 of about 108,237 (301)
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Worst Case Scenario and Stakeholder Group Decision: A 5-6 Meter Sea Level Rise in the Rhone Delta, France [PDF]
Risk policy and public attitudes appear disconnected from research predicting warmer climate partially due to human activity. To step out of this stalled situation, a worst case scenario of a 5-6m sea level rise (SLR) induced by the collapse of the WAIS ...
Athanasios T. Vafeidis +3 more
core
Decompacting a Late Holocene sea-level record from Loch Laxford, northwest Scotland. [PDF]
, 2013 This thesis assesses the degree to which sediment compression affects a Late Holocene sea-level reconstruction from Loch Laxford, northwest Scotland. The reconstruction is based on analysis of a short sediment core (~0.7 m) that records a progressive ...
CULLEN, BENJAMIN,JOHN
core
Coastal use accelerated the regional sea-level rise
, 2013 Coastal zones are highly threatened by global sea-level rise (SLR), but human-induced change in SLR is often neglected in many studies. Identifying the influences of coastal use on regional SLR and their interactions is helpful to effectively respond to ...
Lu, Qingshui +3 more
core +1 more source
Global Dataset of Extreme Sea Levels and Coastal Flood Impacts over the 21st Century
DataA global database of coastal flooding impacts resulting from extreme sea levels is developed for the present day and for the years 2050 and 2100. The database consists of three sub-datasets: the extreme sea levels, the coastal areas flooded by these ...
Ebru Kirezci +5 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Sea-level variability in the Caribbean Sea over the last century
, 2013 Mean sea level rise exposes coasts to increasing risks. For the Caribbean Sea, the regional and local sea-level behaviour is not well known. This study has investigated the sea level behavior in the region at different frequencies during the last century,
Torres Parra, R. Ricardo
core
Australia's coastal living is at risk from sea level rise, but it's happened before [PDF]
, 2018 [Extract] With global sea levels expected to rise by up to a metre by 2100 we can learn much from archaeology about how people coped in the past with changes in sea level.
Turney, Chris +3 more
core
Analysis of Abnormal Sea Level Rise in Offshore Waters of Bohai Sea in 2024
Journal of Marine Science and EngineeringThe primary contribution of this study lies in analyzing the dynamic drivers during two anomalous sea level rise events in the Bohai Sea through coupled numeric modeling using the Weather Research and Forecasting (WRF) model and the Finite-Volume ...
Song Pan +5 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source