Results 111 to 120 of about 11,361,096 (291)

Estimating the cost of sea level rise

Marine Development
Sea level rise exacerbates flood risk for coastal communities globally. Multiple studies have shown that significant property values are already at risk this century, especially in high-emission scenarios. Thus, sea level rise poses major challenges that
Magnus Hieronymus, Jim Hedfors, Lisa Van Well, Gunnel Göransson, Sebastian Bokhari Irminger, Åke Magnusson   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Economy-Wide Impacts of Climate Change: A Joint Analysis for Sea Level Rise and Tourism [PDF]

While climate change impacts on human life have well defined and different origins, the interactions among the diverse impacts are not yet fully understood. Their final effects, however, especially those involving social-economic responses, are likely to
Richard S.J. Tol, Francesco Bosello, Roberto Roson, Andrea Bigano   +3 more
core  

Twentieth-Century Global-Mean Sea Level Rise: Is the Whole Greater than the Sum of the Parts? [PDF]

, 2012
Confidence in projections of global-mean sea level rise (GMSLR) depends on an ability to account for GMSLR during the twentieth century. There are contributions from ocean thermal expansion, mass loss from glaciers and ice sheets, groundwater extraction,
Wada, Y., Fettweis, Xavier, Tamisiea, M. E., Tamisiea, Mark, White, Neil, Church, J. A., Huybrechts, Philippe, Wada, Yoshihide, Box, J.E., Tamisiea, M.E., Marzeion, B., Wake, L. M., Gregory, Jonathan, Church, J.A., Konikow, L., Bierkens, M.F.P., Church, John, Oerlemans, Johannes, Cogley, J.G., Oerlemans, J., van den Broeke, M., Marzeion, Ben, Box, J., Leclercq, P., Gregory, J.M., Leclercq, P.W., Bierkens, Marc, van de Wal, R., Leclercq, P. W., van de Wal, R.S.W., van den Broeke, M R., Cogley, J., Wake, L.M., Broeke, M.R. van den, White, N. J., Box, Jason, Hanna, Edward, Cogley, Graham, Fettweis, X., Bierkens, M. F. P., Van den Broeke, M. R., Van de Wal, R. S. W., Konikow, Leonard, Wake, Leanne, Gregory, J., Konikow, L. F., White, N., Cogley, J. G., Leclercq, Paul, van de Wal, Roderik, Gregory, Jonathan M., Wake, L., Church, J., Huybrechts, P., Tamisiea, M., Bierkens, M., Konikow, L.F., Hanna, E., White, N.J., Tamisiea, E., Box, J. E., van den Broeke, Michiel   +61 more
core   +2 more sources

Atlantic meridional overturning circulation stable over the last 150 years

Quaestiones Geographicae, 2019
The Atlantic Meridional Overturning Circulation (AMOC) describes the northward flow of warm, salty water in the upper layers, and the southward flow of colder water in the deep Atlantic layers.
Parker Albert, Ollier Clifford
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Adaptation to Sea-level Rise in the People’s Republic of China – Assessing the Institutional Dimension of Alternative Organisational Frameworks [PDF]

Global sea-levels are rising due to global warming. Major impacts on the world’s coasts are sand beach erosion, salination of ground water, and inundation.
Maren A. Lau
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source