Results 101 to 110 of about 108,237 (301)
Estimating the cost of sea level rise
Marine DevelopmentSea level rise exacerbates flood risk for coastal communities globally. Multiple studies have shown that significant property values are already at risk this century, especially in high-emission scenarios. Thus, sea level rise poses major challenges that
Magnus Hieronymus +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Economy-Wide Impacts of Climate Change: A Joint Analysis for Sea Level Rise and Tourism [PDF]
While climate change impacts on human life have well defined and different origins, the interactions among the diverse impacts are not yet fully understood. Their final effects, however, especially those involving social-economic responses, are likely to
Richard S.J. Tol +3 more
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State Agency Sea-Level Rise Action Plan for California
, 2022 Numerous state agencies are dedicated to helping California prepare for sea-level rise (SLR). Our vision is to make all of California, including its coastlines, inland areas, and bays and estuaries, resilient to the impacts of SLR, such as flooding ...
Sea-Level Rise Leadership Team +1 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Atlantic meridional overturning circulation stable over the last 150 years
Quaestiones Geographicae, 2019 The Atlantic Meridional Overturning Circulation (AMOC) describes the northward flow of warm, salty water in the upper layers, and the southward flow of colder water in the deep Atlantic layers.
Parker Albert, Ollier Clifford
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Adaptation to Sea-level Rise in the People’s Republic of China – Assessing the Institutional Dimension of Alternative Organisational Frameworks [PDF]
Global sea-levels are rising due to global warming. Major impacts on the world’s coasts are sand beach erosion, salination of ground water, and inundation.
Maren A. Lau
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Plausible responses to the threat of rapid sea-level rise for the Thames Estuary [PDF]
This paper considers the perceptions and responses of selected stakeholders to a scenarion of rapid rise in sea-level due to the collapse of the West Antarctic ice sheet, which could produce a global rise in sea-level of 5 to 6 metres.
Jim Hall +6 more
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