Results 101 to 110 of about 11,361,096 (291)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2008 Here we present a set of regional climate scenarios of sea level rise for the northeast Atlantic Ocean. In this study, the latest observations and results obtained with state-of-the-art climate models are combined.
Geert Jan van Oldenborgh +9 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
THE DOUBLE TRADE-OFF BETWEEN ADAPTATION AND MITIGATION FOR SEA LEVEL RISE: AN APPLICATION OF FUND [PDF]
The effects of adaptation and mitigation on the impacts of sea level rise are studied. Without either, the impacts of sea level rise would be substantial, almost wiping out entire nations before 2100; the global effect is much smaller.
Richard S.J. Tol
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Coastal subsidence and relative sea level rise
Environmental Research Letters, 2014 Subsurface fluid-pressure declines caused by pumping of groundwater or hydrocarbons can lead to aquifer-system compaction and consequent land subsidence.
S E Ingebritsen, D L Galloway
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Using Sea-Level Data to Constrain the Contribution of the Greenland Ice Sheet to Contemporary and Recent Sea-Level Change [PDF]
, 2010 Due to the potentially wide-reaching impacts on climate and sea-level change of a declining Greenland Ice Sheet (GrIS), the mass balance of the past decade has caused concern that the ice sheet is reacting to increased temperatures of the industrial era ...
Wake, Leanne Mary, WAKE, LEANNE,MARY
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Sea-level change and storm surges in the context of climate change [PDF]
, 2000 This paper reviews the latest research in New Zealand surrounding the issues of sea-level rise and extreme sea levels in the context of global warming and variability in the Pacific-wide El Nino– Southern Oscillation (ENSO).
Bell, Robert G. +2 more
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