Results 91 to 100 of about 947,492 (301)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Treading Water: Tools to Help US Coastal Communities Plan for Sea Level Rise Impacts
Frontiers in Marine Science, 2019 As communities grapple with rising seas and more frequent flooding events, they need improved projections of future rising and flooding over multiple time horizons, to assist in a multitude of planning efforts.
Emily A. Smith +11 more
doaj +1 more source
Regional spatial planning assessments for adaptation to accelerated sea level rise - an application to Martinique’s coastal zone [PDF]
Accelerated sea level rise and hurricanes are increasingly influencing human coastal activities. With respect to the projected continuation of accelerated sea level rise and global warming one must count with additional expenses for adaptation strategies
Christine Schleupner
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Spatial Hedonic Models for Measuring the Impact of Sea-Level Rise on Coastal Real Estate [PDF]
This study uses a unique integration of geospatial and hedonic property data to estimate the impact of sea-level rise on coastal real estate in North Carolina.
Ben Poulter +3 more
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Sea-level change and storm surges in the context of climate change [PDF]
, 2000 This paper reviews the latest research in New Zealand surrounding the issues of sea-level rise and extreme sea levels in the context of global warming and variability in the Pacific-wide El Nino– Southern Oscillation (ENSO).
Bell, Robert G. +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Coastal subsidence and relative sea level rise
Environmental Research Letters, 2014 Subsurface fluid-pressure declines caused by pumping of groundwater or hydrocarbons can lead to aquifer-system compaction and consequent land subsidence.
S E Ingebritsen, D L Galloway
doaj +1 more source
Envisioning sea level rise in Golden Gate National Recreation Area [PDF]
, 2020 A step-by-step explanation of how Golden Gate National Recreation Area developed a set of complementary climate change exhibits for various sites in the park, focused on the impacts of sea level ...
Castellini, Laura +2 more
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