Results 81 to 90 of about 108,237 (301)

A Global Perspective on Local Sea Level Changes

open access: yesJournal of Marine Science and Engineering
In 2021, the IPCC published new sea level projections. For the first time, the projections gave insight into expected relative sea level rise locally.
Hessel G. Voortman, Rob De Vos
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sea-level rise rate thresholds.

open access: yes, 2021
Rates of carbon accumulation (g m-2 yr-1) across a range of linear sea-level rise rates (mm yr-1) for each species productivity function and sediment scenario.
Lisa M. Schile-Beers (11586714)   +6 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Landscape Trajectories: sea level rise and future landscapes [PDF]

open access: yes, 2017
Looking out over a quiet sea lapping the shore on a sunny day, it is almost inconceivable to think that it is inexorably rising. The globe is locked into a future of sea level rise of anywhere between 30 cm and 1 metre by 2100, and possibly much higher ...
Stephenson, Janet
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Climate scenarios of sea level rise for the northeast Atlantic Ocean: a study including the effects of ocean dynamics and gravity changes induced by ice melt

open access: yes, 2008
Here we present a set of regional climate scenarios of sea level rise for the northeast Atlantic Ocean. In this study, the latest observations and results obtained with state-of-the-art climate models are combined.
Geert Jan van Oldenborgh   +9 more
core   +1 more source

Treading Water: Tools to Help US Coastal Communities Plan for Sea Level Rise Impacts

open access: yesFrontiers in Marine Science, 2019
As communities grapple with rising seas and more frequent flooding events, they need improved projections of future rising and flooding over multiple time horizons, to assist in a multitude of planning efforts.
Emily A. Smith   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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