Results 41 to 50 of about 9,437,769 (262)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Sea Surface Temperature Variability and Marine Heatwaves in the Black Sea
Remote Sensing, 2022 Marine heatwaves (MHWs) have recently been at the forefront of climate research due to their devastating impacts on the marine environment. In this study, we have evaluated the spatiotemporal variability and trends of sea surface temperature (SST) and MHWs in the Black Sea.
Mohamed, Bayoumy Abdelaziz +2 more
openaire +4 more sources
Global-scale parameters for ecological models
Scientific Data, 2023 Measurement(s) habitat similarity • Time Series Analysis • Principal Component Technology Type(s) Habitat Representativeness Score • Cross-Correlation • Principal Component Analysis Factor Type(s) Sea-bottom and sea-surface dissolved oxygen, salinity ...
Gianpaolo Coro +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Detection of surface temperature anomaly of the Sea of Marmara
Advances in Space Research, 2023 Monitoring sea surface temperature (SST) over a long-term and detecting the anomalies highly contribute to understanding the pre-vailing water quality of the sea. Earth observation satellite images are the key data sources that offer the long-term SST detection in cost and time effective way.
Aylin Tuzcu Kokal +3 more
openaire +2 more sources
Assessment of Climate Changes in the Caspian Sea by trend analyzing the sea surface temperature [PDF]
مخاطرات محیط طبیعی, 2019 Changes the Sea surface temperature and lake can have significant impacts on marine ecosystems and the lives of human societies on the edges of these seas.
Akbar Zahraei +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Sea surface temperatures at Millport [PDF]
Journal of the Marine Biological Association of the United Kingdom, 1959 Sea surface temperatures have been taken daily at Keppel Pier, Millport (55° 44‘ 55“ N. lat.; 4° 54’ 20” W. long.), for the past 10 years (1949–58), the data being included in returns to the Meteorological Office. The records are not given in their standard publication and they are, therefore, presented here to supplement those of Cooper (1958) for ...
openaire +1 more source