Results 71 to 80 of about 8,211,025 (297)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

On the Use of Azimuth Cutoff for Sea Surface Wind Speed Retrieval From SAR

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Peer ...
Yuting Zhu, Giuseppe Grieco, Jiarong Lin, Marcos Portabella, Xiaoqing Wang 0001   +4 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

An intensive study of the currents and general hydrology of an anomalous upwelling area off South West Africa [PDF]

, 1981
Includes bibliographical references.The currents, winds and hydrology of a coastal site of approximately 120 square miles off South West Africa were studied intensively for two weeks during June/July 1978.
Boyd, Alan John
core   +1 more source

Parameterization scheme of the sea surface drag coefficient considering the influence of wave states and sea spray stress

Frontiers in Marine Science
The drag coefficient of the sea surface is crucial for the exchange of momentum between the ocean and atmosphere. The wave state significantly influences the variability of the drag coefficient.
Zeqi Zhao, Jian Shi, Hanshi Wang, Zhenhui Yi, Wenjing Zhang, Xueyan Zhang   +5 more
doaj   +1 more source

X-band COSMO-SkyMed wind field retrieval, with application to coastal circulation modeling [PDF]

Ocean Science, 2013
In this paper, X-band COSMO-SkyMed^© synthetic aperture radar (SAR) wind field retrieval is investigated, and the obtained data are used to force a coastal ocean circulation model.
A. Montuori, P. de Ruggiero, M. Migliaccio, S. Pierini, G. Spezie   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Wind Derivatives: Modeling and Pricing [PDF]

, 2013
Wind is considered to be a free, renewable and environmentally friendly source of energy. However, wind farms are exposed to excessive weather risk since the power production depends on the wind speed, the wind direction and the wind duration.
Zapranis, Achilleas, Alexandridis, Antonis   +1 more
core   +1 more source