Results 71 to 80 of about 202,076 (312)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Planktonic foraminiferal Mg/Ca as a proxy for past oceanic temperatures: a methodological overview and data compilation for the Last Glacial Maximum [PDF]

, 2005
As part of the Multi-proxy Approach for the Reconstruction of the Glacial Ocean (MARGO) incentive, published and unpublished temperature reconstructions for the Last Glacial Maximum (LGM) based on planktonic foraminiferal Mg/Ca ratios have been ...
Tachikawa, Kazuyo, Barker, S., Benway, H., Cacho, I., Barker, Stephen, Barker, S, Benway, Heather, Cacho, I, Cacho, Isabel, Tachikawa, K., Kazuyo, Tachikawa, Benway, H, Tachikawa, K   +12 more
core   +1 more source

Water Movement and Sea Temperature in the English Channel [PDF]

Journal of the Marine Biological Association of the United Kingdom, 1925
During the last three years further evidence has been obtained that water of relatively high salinity, from the Atlantic to the south-west of the entrance, enters the English Channel past Ushant (1).It is of interest to summarize this evidence in view of the suggestion (2) that the English Channel is cut off from the Atlantic for considerable periods ...
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Respiratory response of the deep-sea amphipod Stephonyx biscayensis indicates bathymetric range limitation by temperature and hydrostatic pressure

, 2011
Depth zonation of fauna on continental margins is well documented. Whilst increasing hydrostatic pressure with depth has long been considered a factor contributing significantly to this pattern, discussion of the relative significance of decreasing ...
Sven Thatje, Brown, Alastair, Alastair Brown, Thatje, Sven   +3 more
core   +1 more source

Antarctic sea ice control on ocean circulation in present and glacial climates [PDF]

, 2013
All authors acknowledge support from the National Science Foundation. R.F. acknowledges support from the Breene M. Kerr Chair.In the modern climate, the ocean below 2 km is mainly filled by waters sinking into the abyss around Antarctica and in the North
Burke, Andrea, Ferrari, Raffaele, Adkins, Jess F., Jansen, Malte F., Thompson, Andrew F., Stewart, Andrew L., Jansen, Malte Friedrich, Burke, Andrea, Ph. D. Massachusetts Institute of Technology   +7 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Observations of positive sea surface temperature trends in the steadily shrinking Dead Sea [PDF]

Natural Hazards and Earth System Sciences, 2018
Increasing warming of steadily shrinking Dead Sea surface water compensates for surface water cooling (due to increasing evaporation) and even causes observed positive Dead Sea sea surface temperature trends.
P. Kishcha, R. T. Pinker, I. Gertman, B. Starobinets, P. Alpert   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source