Results 51 to 60 of about 2,368 (248)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Retrieval of Sea Surface Wind Speed Using Spaceborne Millimeter-Wave Radar Measurements [PDF]

IEEE Geoscience and Remote Sensing Letters, 2018
Spaceborne millimeter-wave radars can acquire sea surface backscatter information under clear sky conditions. The analysis based on the classical sea surface scattering model and a matching data set of global CloudSat Cloud Profiling Radar (CPR) observations and AMSR-E sea surface parameters shows that the sea surface scattering cross section is ...
Tao Wen 0004, Zhigang Yao, Zeng L. Zhao, Long F. Lin, Zhi G. Han, Lin D. Guo   +5 more
openaire   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

On Sea Ice Measurement by a C-Band Scatterometer at VV Polarization: Methodology Optimization Based on Computer Simulations

Remote Sensing, 2019
We consider sea ice and water microwave backscatter features at the C-band with vertical transmit and receive polarization and present a method for sea ice/water discrimination using a multiple fixed fan-beam satellite scatterometer.
Alexey Nekrasov, Alena Khachaturian, Evgeny Abramov, Oleg Markelov, Mikhail Bogachev   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A Wind Speed Retrieval Model for Sentinel-1A EW Mode Cross-Polarization Images

Remote Sensing, 2019
In contrast to co-polarization (VV or HH) synthetic aperture radar (SAR) images, cross-polarization (CP for VH or HV) SAR images can be used to retrieve sea surface wind speeds larger than 20 m/s without knowing the wind directions.
Yuan Gao, Changlong Guan, Jian Sun, Lian Xie   +3 more
doaj   +1 more source

Retrieval of Sea Surface Wind Speed from Spaceborne SAR over the Arctic Marginal Ice Zone with a Neural Network

Remote Sensing, 2020
In this paper, we presented a method for retrieving sea surface wind speed (SSWS) from Sentinel-1 synthetic aperture radar (SAR) horizontal-horizontal (HH) polarization data in extra-wide (EW) swath mode, which have been extensively acquired over the ...
Xiao-Ming Li, Tingting Qin, Ke Wu
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source