Results 41 to 50 of about 8,469,039 (290)

Stamina of a non-gasketed flange joint under combined internal pressure and axial loading [PDF]

open access: yes, 2008
The performance of a bolted flange joint is characterized mainly by its 'strength' and 'sealing capability'. A number of numerical and experimental studies have been conducted to study these characteristics under internal pressure loading conditions ...
Abid, M., Awan, A. W., Nash, D. H.
core   +4 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Preparation of a New Borehole Sealing Material of Coal Seam Water Infusion

open access: yesAdvances in Materials Science and Engineering, 2018
To improve the borehole sealing effect of coal seam water infusion, especially that of coal seam with low permeability and high rigidity, this study investigated the performance test optimization of two cement-based sealing materials.
Gang Wang   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Mechanical performance of self-sealing cementitious composites

open access: yes, 2023
Due to increase concern for sustainability and safety of building structures, there has been many studies and development of self-sealing and self-healing concrete.
Sharifah Umairah Binte Syed Gani
core  

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

Analysis and Optimization of Influencing Factors on Sealing Performance of Subsea Wellhead Connector

open access: yesShiyou jixie, 2022
As a key equipment to connect high-pressure wellhead with subsea Christmas tree and prevent the leakage of high-temperature and high-pressure fluid in the well, the subsea connector is faced with extremely severe load.
Liu Shujie   +6 more
doaj  

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

Optimization of K-Shaped Metal Sealing Ring for Subsea Tubing Hanger Based on Response Surface Method

open access: yesModelling and Simulation in Engineering
The K-shaped metal sealing ring of the subsea tubing hanger is a crucial sealing component ensuring wellhead sealing. Optimizing its structure can enhance the sealing performance of the tubing hanger and improve the reliability of subsea wellhead ...
Huan Xie   +4 more
doaj   +1 more source

Experimental Research on Performance of New Gas Drainage Borehole Sealing Material with High Fluidity

open access: yesAdvances in Materials Science and Engineering, 2021
To ensure the sealing effect of gas extraction borehole in underground coal mine and improve the concentration of gas extraction, a kind of high-flow sealing material which can be injected into the microcracks around borehole was developed. The ultrafine
Xin Guo   +3 more
doaj   +1 more source

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