Results 91 to 100 of about 32,884 (310)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A framework for sustainable port planning in inland ports: a multistakeholder approach [PDF]
In the European Union, all levels of government are convinced that an accelerated development of a modal shift towards inland navigation is one of the key requirements for reducing congestion and environmental externalities. This is becoming increasingly
Cathy Macharis, Michael Dooms
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The Post-War Port Industry Development Models: the Effects on the Economic Development of the Port’s Hinterland. [PDF]
The economic development of the port industry that followed the Second World War was based upon two economic theories trends. Until the late 70’s the model based on Keynesianism forms the basic idea for ownership, infrastructure, investment, pricing ...
Angeliki Pardali +1 more
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
EnergiesThe relationship between ports and energy markets is undergoing a transition in their functions as suppliers, consumers, and energy processors. Environmental factors increasingly force the maritime sector to reduce its carbon footprint and improve energy
Małgorzata Bielenia +2 more
doaj +1 more source
The regime of seaports in Ukraine: a complicated way to updating legal regulation
Lex Portus, 2020 The article outlines the advantages and disadvantages of the current legislation of Ukraine in the field of establishing the legal regime of seaports.
Serhii Andrushchenko
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Groupage Cargo Transportation Model
Transport and Telecommunication, 2016 In this work we consider a specific problem of optimal planning of maritime transportation of multiproduct cargo by ships of one (corporate strategy) or several (partially corporate strategy) companies: the core of the problem consists of the existence ...
Aleksejevs Ruslans +3 more
doaj +1 more source