Results 101 to 110 of about 7,043 (308)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Emission Reduction Potential of Hydrogen-Powered Aviation Between Airports in Proximity of Seaports

Aerospace
Green hydrogen will play a crucial role in the future of emission reduction in air traffic in the long-term, as it will completely eliminate CO2 emissions and significantly reduce other pollutants such as contrails and nitrogen oxides.
Nico Flüthmann, Tim Schunkert, Marc Gelhausen, Alexandra Leipold   +3 more
doaj   +1 more source

Legal Regime of Russian Seaports: Security Policy Updates

Lex Portus, 2020
The article is addressed to the groups of regime rules of the Russian Federation (RF) seaports that are of the highest relevance and have undergone significant changes in legal regulation in 2020. The impact of new challenges and threats, destructive for
Elvina Abliakimova, Wang Jianjun
doaj   +1 more source

Industry in seaports in Poland

, 2020
The study aims to classify port cities in Poland in terms of the development of their industrial functions and those in their immediate surroundings. Industrial plants currently operating in the vicinity of seaports were identified in the area where the ...
Bocheński, Tadeusz
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Efficiency of Governance Model and Ownership Structure of Ukrainian Seaports

, 2018
The purpose of this study is to examine the differences and efficiency in governance style of public and private owned seaports in Ukraine. Observation and comparative analysis of models of public and private seaports ownership in the Ukrainian context ...
Kischak, Ivan; Mykolaiv V.O. Sukhomlynskyi National University, Porudeyeva, Tatiana; Mykolaiv V.O. Sukhomlynskyi National University, Glubochenko, Kateryna; Mykolaiv V.O. Sukhomlynskyi National University   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Atlantic Coast U.S. Seaports [PDF]

This fact sheet highlights the major Atlantic container ports of New York/New Jersey, Virginia, Savannah, and Charleston. Containerships and containerized cargo comprise the bulk of vessel calls and most of the vessel value at these seaports along the ...
Menegus, Dominic, Chambers, Matthew
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source