Results 121 to 130 of about 32,884 (310)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Assessing the Port Footprint on Coastal Flood and Erosion Risks

open access: yesEarth's Future
Ports are often perceived as sources of disruption to coastal environments, contributing to sediment imbalance, shoreline erosion and ecosystem service loss.
Moises Alvarez‐Cuesta   +2 more
doaj   +1 more source

Full steam ahead for Texas ports [PDF]

open access: yes
Trade ; North American Free Trade Agreement ; Petroleum industry and ...
José Joaquín López, Keith R. Phillips
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Competition Issues in Restructuring Ports and Railways, Including Brief Consideration of these Sectors in India [PDF]

open access: yes
One important issue facing reformers considering the restructuring of the seaports and freight railways sectors of a developing country is the creation of competition ­ or, alternatively, avoiding the creation or preservation of monopoly power.
Russell Pittman
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Legal status of the sea ports and port policy in Republic of Croatia

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2010
This paper aims at analyzing the legal status of sea ports in the Republic of Croatia, with special overview of the sea ports as maritime domain and at suggesting the objectives of Croatian port policy as well as necessary measures to achieve them ...
Tomislav Batur
doaj  

From centrality to intermediacy in the global transport network? Ukraine’s trials and tribulations as a potential transit country [PDF]

open access: yes, 2015
Ukraine currently is in a very complex economic and political situation, which in itself represents a pivotal point for its further recovery and evolution. Nevertheless, the rise of economic centres in Eastern and Central Europe creates opportunities for
Grushevska, Kateryna, Notteboom, Theo
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

How to Auction an Essential Facility When Underhand Integration is Possible [PDF]

open access: yes
Regulating seaports is difficult in general, even more so for the weak regulatory institutions common in developing countries. For this reason some countries have awarded these facilities via Demsetz auctions, to the port operator that bids the lowest ...
Alexander Galetovic   +2 more
core   +3 more sources

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