Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
An Event-Link Network Model Based on Representation in P-Space. [PDF]
Entropy (Basel)Zhang W, Chen X, Deng W.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
[Mosquito Surveillance at Airports and Seaports to Prevent and Control Emerging Mosquito-borne Diseases in the Republic of Korea, 2024]. [PDF]
Jugan Geongang Gwa JilbyeongJeon S +9 more
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Evaluation of port competitiveness along China's "Belt and Road" based on the entropy-TOPSIS method. [PDF]
Sci Rep, 2023 Wang J, Mo L, Ma Z.
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Competitiveness and strategic positioning of seaports: the case of Iberian Seaports
, 2012 The global market, with its extensive business networks and complex logistics systems, poses a high degree of uncertainty to the seaport industry and leaves seaport managers facing questions over just how to effectively respond to the ongoing market dynamics.
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Invasive mosquito surveillance in the United Kingdom 2020 to 2024: First detection of Aedes aegypti eggs in the UK and further detection of Aedes albopictus. [PDF]
PLOS Glob Public HealthJohnston CJ +23 more
europepmc +1 more source
No country is safe from a pandemic: insights into small countries' COVID-19 experiences. [PDF]
Eur J Public Health, 2023 Cuschieri S, Bejko D, Stranges S.
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THE DECARBONIZATION OF SEAPORTS: AN OVERVIEW OF SELECTED MEASURES [PDF]
Ports are considered critical infrastructure as they play an important role in international trade and overall economic growth. There are around 4,000 ports worldwide, of which around 1,200 are located in Europe alone. Ports around the world face the same challenge of providing competitive services while ensuring that the negative impact on the ...
Marina Zanne +3 more
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