Results 121 to 130 of about 32,565 (293)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Assessing the Port Footprint on Coastal Flood and Erosion Risks

open access: yesEarth's Future
Ports are often perceived as sources of disruption to coastal environments, contributing to sediment imbalance, shoreline erosion and ecosystem service loss.
Moises Alvarez‐Cuesta   +2 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Legal status of the sea ports and port policy in Republic of Croatia

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2010
This paper aims at analyzing the legal status of sea ports in the Republic of Croatia, with special overview of the sea ports as maritime domain and at suggesting the objectives of Croatian port policy as well as necessary measures to achieve them ...
Tomislav Batur
doaj  

Role of Seaports and Imported Rats in Seoul Hantavirus Circulation, Africa. [PDF]

open access: yesEmerg Infect Dis, 2023
Castel G   +4 more
europepmc   +1 more source

Globalization and Inequality: Evidence from Within China [PDF]

open access: yes
In this paper, we provide a case study of the impact of globalization on income inequality using data across Chinese regions. The literature on cross-country studies has been criticized because differences in legal systems and other institutions across ...
Shang-Jin Wei, Yi Wu
core  

U.S. Customs and Border Protection: Trade Facilitation, Enforcement, and Security [PDF]

open access: yes, 2013
[Excerpt] This report describes and analyzes import policy and CBP’s role in the U.S. import process. (The report does not cover CBP’s role in the U.S. export control system.) The first section of the report describes the three overarching goals of U.S ...
Jones, Vivian C, Rosenblum, Marc R
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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