Results 111 to 120 of about 9,393,101 (284)

Seismic slope permanent displacement calculation based on improved Newmark model using upper bound solution of plastic mechanics

Scientific Reports
Based on a review of the fundamental principles of the Newmark sliding displacement method, this paper proposes an improved approach based on the upper bound solution of plastic mechanics, drawing on the theory of Academician Zuyu Chen, which states that
Pengxu Jing, Wenbo Zheng, Li Li, Baokun Ning, Mingyong Lu, Qingyi Yang, Yanyun Nan, Jing Li, Yifan Xu, Jingjing Liu   +9 more
doaj   +1 more source

Search conversion journeys and the missed opportunity of associated keywords

Frontiers in Communication
We map the conversion journey (i.e., the path a costumer takes to purchase a product or service) for phones, laptops, and vehicles (i.e., cars and trucks) by analyzing a massive corpus of online searches on Bing by people in the U.S. during 2021. We show
David M. Rothschild, Coen Needell, Joe Veverka, Elad Yom-Tov   +3 more
doaj   +1 more source

COMPUTER SEARCH VERSUS TECHNICAL-SCIENTIFIC FINDING [PDF]

Challenges of the Knowledge Society, 2018
The study intends to establish delimitation between computer search and technical-scientific finding, having as a starting point certain cases encountered in the judicial practice when the law enforcement authorities confused the scopes of these two ...
Radu SLĂVOIU
doaj  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Corrections to the apparent value of the cosmological constant due to local inhomogeneities

, 2011
Supernovae observations strongly support the presence of a cosmological constant, but its value, which we will call apparent, is normally determined assuming that the Universe can be accurately described by a homogeneous model.
A. Ishibashi, A.E. Romano, A.E. Romano, A.E. Romano, A.E. Romano, Antonio Enea Romano, B.J. Barris ., C. Clarkson, C. Hellaby, D. Edwards, G. Lemaître, H. Bondi, J. Garcia-Bellido, J. Garcia-Bellido, J. Garcia-Bellido, M.-N. Célérier, N. Mustapha, P.F. Byrd, Pisin Chen, S. Alexander, Supernova Cosmology Project collaboration, Supernova Cosmology Project collaboration, Supernova Search Team collaboration, Supernova Search Team collaboration, Supernova Search Team collaboration, WMAP collaboration, WMAP collaboration, Y. Nambu   +27 more
core   +1 more source

Research Re: search & Re-search

Search algorithms are often categorized by their node expansion strategy. One option is the depth-first strategy, a simple backtracking strategy that traverses the search space in the order in which successor nodes are generated. An alternative is the best-first strategy, which was designed to make it possible to use domain-specific heuristic ...
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Moving towards Adaptive Search [PDF]

, 2009
Information retrieval has become very popular over the last decade with the advent of the Web. Nevertheless, searching on the Web is very different to searching on smaller, often more structured collections such as intranets and digital libraries.
De Roeck, A, Dignum, S, Fasli, M, Kim, Y, Kruschwitz, U, Song, D   +5 more
core