Results 81 to 90 of about 101,135 (277)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Chapter Unmanned Ground Robots for Rescue Tasks [PDF]
, 2017 This chapter describes two unmanned ground vehicles that can help search and rescue teams in their difficult, but life-saving tasks. These robotic assets have been developed within the framework of the European project ICARUS.
Berns, Karsten +4 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
IEEE AccessAvalanches claim numerous lives annually, underscoring the critical need for rapid and reliable rescue solutions. This paper presents an innovative autonomous drone system explicitly designed to enhance avalanche search and rescue (SAR) operations in ...
Jedrzej Stasik, Tomasz Szandala
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The modified crABCDE treatment algorithm as recommendation in extreme cold
Resuscitation PlusTrauma care prioritizes life-threatening conditions using the ABCDE algorithm based on the principle “treat first what kills first”. As for catastrophic hemorrhage, a leading preventable cause of death in trauma, modifications of this algorithm are ...
Raimund Lechner +5 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Design & development of the RESCUE MIMS, V2
, 2021 The RESCUE-MIMS device delivered inside the SnR project can be used for the early detection of toxic environments for the first responders in terms of hazardous Volatile Organic Compounds (VOCs) or semi-Volatile Organic Compounds (semi-VOCs) identified ...
Hana Gharrad +9 more
core +1 more source
Drones, 2019 Search and rescue (SAR) is a vital line of defense against unnecessary loss of life. However,in a potentially hazardous environment, it is important to balance the risks associated with SARaction.
Claire Burke +6 more
doaj +1 more source