Results 61 to 70 of about 101,135 (277)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Search and rescue: A case study of design flexibility [PDF]

1988 Winter Simulation Conference Proceedings, 1988
This paper is a case study description of the major techniques used in the design of a Search and Rescue (SAR) model, how the methods contribute to flexibility, and how these software engineering principles relate to a formal methodology (Zeigler 1987) that has been proposed specifically for simulation development.
Keneth N. McKay, Jan Laube
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Picket anchoring systems in trench rescue operations

Geoenvironmental Disasters
Background Trenching and excavation work continues to be among the most lethal activities in the construction sector with trench collapses presenting extreme hazards to both workers and rescuers.
Oliver-Denzil S. Taylor, Beena Ajmera, Ron Zawlocki   +2 more
doaj   +1 more source

Improving operational use of post-disaster damage assessment for Urban Search and Rescue by integrated graph-based multimodal remote sensing data analysis

Progress in Disaster Science
This work investigates the application of remote sensing technologies within the specific operational context of emergency urban search and rescue (USAR) efforts post-disaster. We thoroughly investigate two innovative methodologies, each tailored to meet
Sivasakthy Selvakumaran, Iain Rolland, Luke Cullen, Rob Davis, Joshua Macabuag, Charbel Abou Chakra, Nanor Karageozian, Amir Gilani, Christian Geiβ, Miguel Bravo-Haro, Andrea Marinoni   +10 more
doaj   +1 more source

Medical emergencies at sea: an analysis of ambulance-supported and autonomously performed operations by lifeboat crews

BMC Emergency Medicine, 2023
Background Very little data is available about the involvement of lifeboat crews in medical emergencies at sea. The aim of this study is to analyze the medical operations at sea performed by the Royal Netherlands Sea Rescue Institution (KNRM).
Daphne M. Messelink, Gert-Jan van der Ploeg, Theo van der Linden, Roos D. Flameling, Joost J. L. M. Bierens   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Safe Search and Rescue Operations Based on Autonomous Robots: A Systematic Review of the General System Architecture

IEEE Access
Over the past few years, remarkable progress has been made in Autonomous Robotic Systems (ARSs) due to their multidisciplinary nature and applications. Among the most in-demand applications is the Search and Rescue (SAR) task, particularly in high-risk ...
Abbas Aqeel Kareem, Ahmed Jabbar Abid, Dalal Abdulmohsin Hammood, Ali Abdulelah Al-Naji, Javaan Chahl   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source