Results 51 to 60 of about 428,084 (271)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Safe Search and Rescue Operations Based on Autonomous Robots: A Systematic Review of the General System Architecture

IEEE Access
Over the past few years, remarkable progress has been made in Autonomous Robotic Systems (ARSs) due to their multidisciplinary nature and applications. Among the most in-demand applications is the Search and Rescue (SAR) task, particularly in high-risk ...
Abbas Aqeel Kareem, Ahmed Jabbar Abid, Dalal Abdulmohsin Hammood, Ali Abdulelah Al-Naji, Javaan Chahl   +4 more
doaj   +1 more source

A Location-Aware Waypoint-Based Routing Protocol for Airborne DTNs in Search and Rescue Scenarios

Sensors, 2018
In this paper, we propose GeoSaW, a delay-tolerant routing protocol for Airborne Networks in Search and Rescue scenarios. The protocol exploits the geographical information of UAVs to make appropriate message forwarding decisions.
Armir Bujari, Carlos T. Calafate, Juan-Carlos Cano, Pietro Manzoni, Claudio E. Palazzi, Daniele Ronzani   +5 more
doaj   +1 more source

Collaborative information sensemaking for multi-robot search and rescue [PDF]

, 2015
In this paper, we consider novel information sensemaking methods for search and rescue operations that combine principles of information fusion and collective intelligence in scalable solutions.
Lee, PJ, Lewis, M, Zadorozhny, V
core   +1 more source

An evolutionary computation approach for optimizing connectivity in disaster response scenarios [PDF]

, 2012
This article presents an evolutionary computation approach for increasing connectivity in disaster scenarios. Connectivity is considered to be of critical importance in disaster scenarios due to constrained and mobile conditions.
Alander, Aschenbruck, Aschenbruck, Aschenbruck, Aschenbruck, Asimakopoulou, Bai, Bani-Yassein, Bao, Beraldi, Berg, Boukerche, Camp, D.G. Reina, Dengiz, E. Asimakopoulou, F. Barrero, Fall, Goldberg, Hanzo, Lakshmi, Layuan, Martinez-Torres, Michalewicz, Murray, N. Bessis, Panichpapiboon, Perkins, Reina, Reina, Reina, Royer, S.L. Toral Marín, Toral, Tuna, Tzu-Chiang, Vecchio, Xu, Zhou   +38 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Haiti : the South African perspective [PDF]

, 2010
The original publication is available at http://www.samj.org.zaBackground and problem statement. The South African response to the Haitian earthquake consisted of two independent nongovernment organisations (NGOs) working separately with minimal contact.
De Vries, Shaheem, Docrat, Fathima, Kramer, Efraim B., Smith, Wayne P., Van Hoving, Daniel J., Wallis, Lee A.   +5 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Functionality of the Search and Rescue Transponder (SART) in Maritime Search and Rescue Actions

Applied Sciences
In this article, the authors present contemporary problems in search and rescue operations at sea. The research focuses on the detection of the SART (Search and Rescue Transponder) device.
Marzena Malyszko, Miroslaw Wielgosz, Brunon Rzepka   +2 more
doaj   +1 more source

Multipurpose UAV for search and rescue operations in mountain avalanche events

Geomatics, Natural Hazards & Risk, 2017
This paper presents a multipurpose UAV (unmanned aerial vehicle) for mountain rescue operations. The multi-rotors based flying platform and its embedded avionics are designed to meet environmental requirements for mountainous terrain such as low ...
Mario Silvagni, Andrea Tonoli, Enrico Zenerino, Marcello Chiaberge   +3 more
doaj   +1 more source