Results 141 to 150 of about 2,930 (240)

Effects of Intubation Duration on Trachea: A Histopathological Study

The Laryngoscope, EarlyView.
This study evaluated the histopathological effects of prolonged endotracheal intubation on the human trachea using biopsy specimens obtained during tracheotomy. Prolonged intubation was associated with progressive inflammatory and structural changes, with tracheal dilatation and perichondritis increasing significantly after 14 days.
Osman Kilic, Serdal Celik, Cemal Gundogdu, Berina Slipcevic, Ayse Yasemin Gunduz, Hamdi Sirac Gundogdu, M. Tayyar Kalcioglu   +6 more
wiley   +1 more source

A Search and Rescue

NewA search and Rescue (SAR) helicopter sits on the runway at St.Johns now stationed in Gander, the helicopters were based on the island following intense criticism of SAR in Newfoundland during the San Juan and Gabriella disasters.2 Col x

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Impact of Monomer Purity on the Acid‐Catalyzed ROP of Sarcosine N‐Carboxyanhydrides: A Comparative Study of Phosgene‐Free Synthetic Routes toward High‐Molecular‐Weight Polysarcosine

Macromolecular Rapid Communications, EarlyView.
A robust, phosgene‐free oxalyl chloride/silyl‐mediated route yields high‐purity sarcosine N‐carboxyanhydride (Sar‐NCA) by eliminating residual impurities that compromise polymerization control. This strategy enables well‐defined, acid‐catalyzed ring‐opening polymerization under ambient conditions, producing polysarcosine with Mn up to 186 kDa and ...
Anna Golunova, Ana Elena Morán Espinoza, Jana Dvořáková, Petr Hezký, Andres de los Santos Pereira, Lenka Kotrchová, Vladimír Proks   +6 more
wiley   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Diverging Cervical Cancer Burden in Africa in the Context of WHO's Elimination Strategy: Insights From GBD 2023

Med Research, EarlyView.
The study highlights the rising cervical cancer burden in Africa, where rates have increased since 1990. Key challenges include structural health inequalities, low HPV vaccination coverage, and limited screening. Projections suggest a continued increase in incidence, deaths, and DALYs by 2038, diverging further from global trends.
Yedong Huang, Shun Chen, Shiqi Ren, Jingwei Zhao, Ziheng Wang, Zhichao Lu, Weiye Qian, Jian Wang, Ting Zhou, Yifan Wang, Zhixin Jiao, Chenyizhe Yuan, Yucheng Hou, Dong Liu, Zhining Liu, Aimin Xu, Li Liu, Qiaojun Hong, Lin Zhang   +18 more
wiley   +1 more source

Point of Care Testing and Recombinase Polymerase Amplification

Journal of Clinical Laboratory Analysis, EarlyView.
Manfred Weidmann, Ahmed Abd El Wahed
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Unmanned Aerial Systems for SAR operations in avalanche events

, 2017
Unmanned Aerial Systems (UAS) are nowadays becoming more and more popular in several applications. Even though a complete regulation is not yet available all over the world, researches, tests and some real case applications are wide spreading.
mario silvagni
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