Results 151 to 160 of about 2,930 (240)

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Post‐Mortem Nasal Swab Testing to Reveal Hidden Respiratory Pathogens: Unlocking Public Health Insights in Bangladesh

Medicine Advances, EarlyView.
Respiratory deaths in Bangladesh are frequently assigned non‐specific causes because of limited diagnostic information. Through stakeholder consultations, key informant interviews, microbiologist consultations, and literature review, 11 priority respiratory pathogens were identified for potential detection using post‐mortem nasal swab testing and ...
Ridwana Maher Manna, Aniqa Tasnim Hossain   +1 more
wiley   +1 more source

Frailty Severity and Voice Outcomes After Type 1 Thyroplasty

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Frailty is associated with high mortality and morbidity, even for low‐risk procedures. The role of frailty in postoperative quality of life is not well characterized. We studied the relationship between frailty and voice outcomes after type 1 thyroplasty. Study Design Retrospective chart review.
Ari D. Schuman, Alex H. Beck, Louis Abarca, Madeline Brungardt, Julina Ongkasuwan, Adam R. Szymanowski   +5 more
wiley   +1 more source

Association of Nasal Anatomy, Airflow, and Surgery With Olfactory Outcomes: A State‐of‐the‐Art Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Olfactory function is influenced by nasal airflow dynamics and anatomical variations within the nasal cavity. This narrative review evaluates how nasal anatomy and airflow relate to olfactory outcomes, with a particular focus on olfactory changes following functional nasal surgery. Data Sources PubMed.
Joshua Ferreira, Alfonso Luca Pendolino, Riccardo Pappalardo, Peter J. Andrews   +3 more
wiley   +1 more source

Mitigating Health Disparities Through Empathetic Policymaking During Times of Crisis

Public Administration and Development, EarlyView.
ABSTRACT The COVID‐19 pandemic greatly exacerbated the existing disparities and inequities in health and healthcare among historically marginalized populations. Today, these impacts still echo. These persistent structured inequities erode the public's trust in government, lead to failure in public policies, and result in worse health consequences ...
Yali Pang, Brittany Keegan, Robyn D. McDougle   +2 more
wiley   +1 more source

Location of natural disasters search and resque (SAR) units in sectors

, 2016
80
openaire   +2 more sources

Globalizing Comparative Public Administration With Integrative Contextualization: State Autonomy in the Developmental Path of Hong Kong and Singapore

Public Administration and Development, EarlyView.
ABSTRACT The lack of a common variable for comparison has been a major obstacle to the development of Comparative Public Administration (CPA). State autonomy enables an integrative contextualization approach, allowing both the analysis of contextual individual country experiences and the generation of generalized comparable knowledge.
Wilson Wong
wiley   +1 more source

High‐intensity interval training vs. moderate‐intensity continuous training in COVID‐19 survivors (COVIDEX): A randomized clinical trial on feasibility and short‐term efficacy

PM&R, EarlyView.
Abstract Background High‐intensity interval training (HIIT) and moderate‐intensity continuous training (MICT) have been widely studied in individuals with chronic conditions. However, no studies have compared these two exercise modalities in COVID‐19 survivors. Objective To compare the feasibility, safety, adherence, and short‐term efficacy of HIIT and
Vinicius Afonso Gomes, William de Suzart, Fabiane Costa Santos Fontoura, Micheli Bernardone Saquetto, Ana Paula Bastos Nery, Bruno Prata Martinez, Thaiana Marcelino Ramos, Samara Souza Santos, Paulo Matheus Petersen Rivas, Ana Paula Andrade Barreto, Marcelo Chalhoub Coelho Lima, Mansueto Gomes‐Neto   +11 more
wiley   +1 more source