Results 41 to 50 of about 2,930 (240)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source

Intelligent mobile systems for indoor search and rescue (SAR) applications

, 2022
S.36-37In the future, mobile robots will find numerous civil and military applications, such as supporting human rescue teams in dangerous situations. The technology roadmap for "Intelligent mobile systems (IMS) for indoor SAR applications" outlines the ...
Pinzger, Britta, Müller, Martin, Müller, Sabine   +2 more
core   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

A maritime search and rescue path planning method based on improved DQN

International Journal of Digital Earth
In maritime search and rescue (SAR) missions, search path planning is a key factor in determining rescue efficiency and success rate. Due to the limitations of traditional algorithms – which rely heavily on manual decision-making, are strongly subjective,
Bo Ai, Haolin Cai, Qiqi Zhu, Chongjun Feng, Nan Xu   +4 more
doaj   +1 more source

An Improved Search and Rescue Algorithm for Global Optimization and Blood Cell Image Segmentation

Diagnostics, 2023
Image segmentation has been one of the most active research areas in the last decade. The traditional multi-level thresholding techniques are effective for bi-level thresholding because of their resilience, simplicity, accuracy, and low convergence time,
Essam H. Houssein, Gaber M. Mohamed, Nagwan Abdel Samee, Reem Alkanhel, Ibrahim A. Ibrahim, Yaser M. Wazery   +5 more
doaj   +1 more source

Considerations for flight testing of search and rescue (SAR) innovations

The Journal of Search and Rescue
Flight testing of new aircraft, equipment and systems is mandatory in the aviation industry to establish and verify the airworthiness of any new airborne product as determined by the appropriate authority, for example the Federal Aviation Administration (FAA) in the United States or the European Union Aviation Safety Agency (EASA) in Europe.
Christopher Bennett, Jane Hodgkinson, Jim Nixon   +2 more
openaire   +2 more sources

Training and Support system in the Cloud for improving the situational awareness in Search and Rescue (SAR) operations [PDF]

2014 IEEE International Symposium on Safety, Security, and Rescue Robotics (2014), 2014
In this paper, a Training and Support system for Search and Rescue operations is described. The system is a component of the ICARUS project (http://www.fp7-icarus.eu) which has a goal to develop sensor, robotic and communication technologies for Human Search And Rescue teams.
Michal Pelka, Karol Majek, Janusz Bedkowski, Pawel Musialik, Andrzej Maslowski, Geert De Cubber, Haris Balta, António Coelho 0001, Ricardo Gonçalves 0005, Ricardo Baptista, Jose M. Sanchez, Shashank Govindaraj   +11 more
openaire   +1 more source

From Displacement to Angle: Diamond‐Based 3D Rotation Sensing for High‐Precision Cellular Force Measurement

Advanced Science, EarlyView.
Cellular forces are traditionally inferred from displacement measurements, which lack rotational information and are constrained by linear model assumptions. This work replaces displacement with rotational angle for the fundamental mechanical readout.
Linjie Ma, Bicong Wang, Tai Nam Yip, Jiahua Zhang, Yicheng Wang, Luyao Zhang, Yong Hou, Yuan Lin, Zhiqin Chu   +8 more
wiley   +1 more source