Results 61 to 70 of about 2,873,297 (289)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Air and Water Flowrate Optimisation for a Fan Coil Unit in Heat Pump Systems [PDF]

open access: yes, 2012
The degradation in efficiency of auxiliary components in heating/cooling systems when operating at part load is frequently reported. Through the use of variable speed components, the supplied capacity can be reduced to match the required load and hence ...
Kilian, Edwards, Finn, Donal P.
core   +1 more source

Tracking the eye non-invasively: Simultaneous comparison of the scleral search coil and optical tracking techniques in themacaque monkey

open access: yesFrontiers in Behavioral Neuroscience, 2012
From human perception to primate neurophysiology, monitoring eye position is critical to the study of vision, attention, oculomotor control, and behavior.
Daniel L. Kimmel   +2 more
doaj   +1 more source

A Detection System with Spider Web Coil-Based Wireless Charging and an Active Battery Management System

open access: yesИзвестия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2021
The article presents a detection system with spider web coil-based wireless charging. Commonly available metal detectors are sold as handheld systems, which enable only progressive, lengthy, time-consuming search.
J. Pokorny   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Flipper coil closure of patent ductus arteriosus [PDF]

open access: yes, 2007
Transcatheter closure of patent ductus arteriosus is now a well established therapeutic option. In this paper, we illustrate step by step the technique of Flipper coil closure of small (
DeGiovanni, Joseph V., Grech, Victor E.
core  

Electronically switchable sham transcranial magnetic stimulation (TMS) system. [PDF]

open access: yesPLoS ONE, 2008
Transcranial magnetic stimulation (TMS) is increasingly being used to demonstrate the causal links between brain and behavior in humans. Further, extensive clinical trials are being conducted to investigate the therapeutic role of TMS in disorders such ...
Fumiko Hoeft   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Transmitter & Receiver Coil Design for Open Area Concealed Weapon Detection System [PDF]

open access: yes
Individuals carrying guns, knives and other weapon type metal objects are a threat to general public safety and thus the detection of such weapons is a priority in airports, schools and military checkpoints etc.
Pati, Prasanta, Mather, Peter
core   +4 more sources

Rotor Position Detection Method for Permanent Magnet Synchronous Motors Based on Search Coil Mutual Inductance

open access: yesIET Electric Power Applications
This paper addresses the problem of traditional search coils being unable to detect the rotor position of permanent magnet synchronous motors (PMSMs) in low‐speed regions.
Xinmin Li   +5 more
doaj   +1 more source

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