Results 51 to 60 of about 130,794 (313)
Research and Design on Personalized Mobile Search Agent
Dianxin kexue, 2013 Mobile search has become one of the most important mobile internet applications. With the development of intelligent terminal technology and search engine technology，it’s possibility to improve the user’s search experience.
Zhenwei He +3 more
doaj +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
IEEE AccessOnline content availability, commercial viability, and technological advancements for English and European languages direct mainstream search engines to prioritize the search results of these high-resource languages.
Muhammad Amir Mehmood, Bilal Tahir
doaj +1 more source
Search engines as a security threat
Computer, 2001 Because they implement vulnerable security policies, search engines are excellent tools for helping hackers to attack machines anonymously, search for easy targets or gather confidential data. Securing all channels against hackers trying to penetrate a vulnerable system isn't possible, but there is no reason for search engines to be wide-open channels ...
Julio César Hernández Castro +3 more
openaire +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Antecedents and Outcomes of Search Engines Loyalty: Designing a model of Iranian Users Loyalty
تحقیقات بازار یابی نوین, 2013 This paper aims to design proposed model for search engine designers to promote loyalty levels of search engine users. This is a descriptive survey study. The statistical population of the research is composed of Ferdowsi University students.
Alireza Hadadian +3 more
doaj