Results 71 to 80 of about 3,804,907 (383)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

From search engine optimisation to search engine marketing management: development of a new area for information systems research [PDF]

open access: yes, 2010
Search Engine Optimisation was a term used by web developers in the late 90s to highlight the importance of increasing a website’s position in search engines’ results.
Chadwick, C, Fletcher, G, Heinze, A
core   +1 more source

Ordinary Search Engine Users Carrying Out Complex Search Tasks

open access: yes, 2012
Web search engines have become the dominant tools for finding information on the Internet. Due to their popularity, users apply them to a wide range of search needs, from simple look-ups to rather complex information tasks.
Lewandowski, Dirk   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Special Intelligent Search Engine

open access: yesIranian Journal of Information Processing & Management, 2011
In this paper Special Intelligent Search Engine (SISE) design has been introduced. Also System architecture and methods of this component of its intelligent search engine and features have been described.
Reza Sarabadani, Hossein Shirazi
doaj  

CWM Global Search—The Internet Search Engine for Chemists and Biologists

open access: yesFuture Internet, 2010
CWM Global Search is a meta-search engine allowing chemists and biologists to search the major chemical and biological databases on the Internet, by structure, synonyms, CAS Registry Numbers and free text. A meta-search engine is a search tool that sends
Hans-Jürgen Himmler, Alexander Kos
doaj   +1 more source

Search Engine Users [PDF]

open access: yes, 2005
Presents findings from a survey conducted in May and June 2004. Looks at confidence in search ability; satisfaction with results; overall trust of search engines; and demographic differences among ...
Deborah Fallows
core  

Experience of Developing a Meta-Semantic Search Engine

open access: yes, 2013
Thinking of todays web search scenario which is mainly keyword based, leads to the need of effective and meaningful search provided by Semantic Web. Existing search engines are vulnerable to provide relevant answers to users query due to their dependency
Joshi, Gajanan   +4 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

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