Results 111 to 120 of about 85,436,355 (282)

The search for meaning among persons living with recurrent cancer

open access: yes, 1992
Attributions theory suggests that persons experiencing a negative or unexpected life event, search for meaning. The experience of having cancer is one such life event, and there is substantial evidence that persons living with cancer search for meaning ...
Taylor, Elizabeth Johnston
core  

Review of Humanist geography: An individual’s search for meaning. Staunton, by Yi-Fu Tuan

open access: yes, 2014
Review of Yi-Fu Tuan. (2012). Humanist Geography – An Individual’s Search for Meaning. George F. Thompson Publishing.
Lenart, Bartlomiej A.
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

In search of the meaning of Boorong:Goop

open access: yes, 2018
In search of the meaning of Boorong ...
Louis N. Lane (13805305)
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Alienation and Search for Meaning in John Williams' Stoner

open access: yesJurnal Poetika
While many individuals in modern society experience alienation, few literary works capture this existential condition as profoundly as John Williams’ Stoner.
Bima Satria Naufal Prahananda   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Meaning in Life: Search and Presence

open access: yes
Testing reciprocal effects between search for meaning and presence of meaning in life using longitudinal panel ...
Xyle Ku
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

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