Results 101 to 110 of about 2,195,151 (316)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The mediating effect of community identity and the moderating effect of social comparison in the relationship between residential mobility and sense of meaning in life

Frontiers in Psychology
IntroductionNumerous studies have documented the adverse effects of residential mobility; however, its relationship with the sense of meaning in life remains underexplored.
Song Weifang, Duan Majie, Zhao Na
doaj   +1 more source

Hannah Arendt: the search for some meaning on the Jewish question [PDF]

, 2010
La filosofía de Hannah Arendt es una propuesta que trata de dar remedio a los males de la política apostando por la democracia esencial. En la Europa de los años treinta del pasado siglo el totalitarismo era, sin duda, el mayor mal que jamás la política ...
Rodríguez Ortiz, M. Victoria
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The loss of a child, bereavement and the search for meaning: A systematic review of the most recent parental interventions. [PDF]

Curr Psychol, 2022
Pelacho-Rios L, Bernabe-Valero G.
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Beyond radicalization: the 3N model and its application to criminal attitudes in high-risk contexts

Frontiers in Psychology
IntroductionThis research integrates criminological and psychological literature by applying the 3N model of radicalization to predict criminal attitudes. Specifically, we conceptualize “need” as the search for meaning, “networks” as deviant associations,
Jocelyn J. Bélanger, Michael Wolfowicz, Hayat Mohammad, Roberto M. Lobato, Michelle Blaya Burgo, Laura Rico-Bustamante, José M. Martín-Criado, Manuel Moyano   +7 more
doaj   +1 more source

How the COVID-19 Pandemic and its Consequences Affect the Presence of and Search for Meaning of Life: A Longitudinal Study. [PDF]

J Happiness Stud, 2023
Baños RM, Desdentado L, Vara MD, Escrivá-Martínez T, Herrero R, Miragall M, Tomás JM.   +6 more
europepmc   +1 more source

Finding the Original Meaning of American Criminal Procedure Rights: Lessons from Reasonable Doubt’s Development [PDF]

, 2012
[Excerpt] “The prosecution must prove every element of the crime beyond a reasonable doubt for a valid conviction. The Constitution nowhere explicitly contains this requirement, but the Supreme Court in In re Winship1 stated that due process commands it.
Jonakait, Randolph N.
core   +2 more sources