Results 81 to 90 of about 85,436,355 (282)

Childhood trauma and meaning in life in university freshmen: a chain mediation model and its experimental causal test

open access: yesBMC Psychology
Background The formation of meaning in life is a pivotal developmental task during the transition to university, yet its potential undermining by early adverse experiences remains unclear. Building on meaning-making and developmental systems perspectives,
Gaoquan Zhao   +5 more
doaj   +1 more source

SCIENCE‐AND‐RELIGION AND THE SEARCH FOR MEANING

open access: yesZygon, 1996
. A survey and interpretation is offered of the broad range of contemporary thinking that concerns itself with the relationships between religion and science.
doaj   +2 more sources

Gwen Harwood - A Search for Meaning [PDF]

open access: yes, 2017
If there is a pattern to the search for meaning in life in Gwen Harwood's poetry, it is to be found in the life cycle of birth, growth, marriage, motherhood, ageing and death - her response to such events in her own life pervade much of her ...
Beck, Margie
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How I cracked nature’s code for positive mental health: introduction and my search for meaning

open access: yes
From: Wong, P. T. P. (2019, July 6). How I cracked nature’s code for positive mental health: introduction and my search for meaning [President’s Column]. Positive Living Newsletter.
paul T P Wong
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

In search of science, in search of meaning [PDF]

open access: yesEPJ Web of Conferences, 2012
Just before passing Pierre Valiron made the last corrections of a manuscript for a book called Chercheurs en science, Chercheurs de sens (Editions de l'Atelier, Paris, 2009). I coauthored this book with him.
openaire   +2 more sources

One size does not fit all - multimodal search on mobile and desktop devices with the I-SEARCH search engine [PDF]

open access: yes, 2012
International audienceIn this paper, we report on work around the I-SEARCH EU (FP7 ICT STREP) project whose objective is the development of a multimodal search engine targeted at mobile and desktop devices.
Sutton, Lorenzo   +26 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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